Protein profile

KP13_02131

putative HTH-type transcriptional regulator matA

Genome: KpKP13

Gene: matA AHE46131.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSF3
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Amino acids 180
Annotations 2
Features 18
PDB binders 0
Druggability 0.601

Overview

Basic information about this protein and its source genome.

Accession
KP13_02131
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
matA AHE46131.1
Status
annotated
Amino acids
180
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
90.556
DEG E-value
9.11e-117
Localization
Unknown
ColabFold pLDDT
89.25

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.601
Structure A0A0H3GSF3
Pocket Pocket 3
P2Rank 0.04
Structure A0A0H3GSF3
Pocket Pocket 1
ColabFold model
FPocket 0.606 · Pocket 6
P2Rank 0.065 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 10 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
122 180 ProSiteProfiles PS50043 LuxR-type HTH domain profile.
122 180 InterPro IPR000792 Transcription regulator LuxR, C-terminal
143 159 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
143 159 InterPro IPR000792 Transcription regulator LuxR, C-terminal
129 143 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
129 143 InterPro IPR000792 Transcription regulator LuxR, C-terminal
159 171 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
159 171 InterPro IPR000792 Transcription regulator LuxR, C-terminal
129 171 Pfam PF00196 Bacterial regulatory proteins, luxR family
129 171 InterPro IPR000792 Transcription regulator LuxR, C-terminal
123 171 SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators
123 171 InterPro IPR016032 Signal transduction response regulator, C-terminal effector
102 175 Gene3D G3DSA:1.10.10.10 -
102 175 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
126 175 SMART SM00421 luxrmega5
126 175 InterPro IPR000792 Transcription regulator LuxR, C-terminal
130 171 CDD cd06170 LuxR_C_like
130 171 InterPro IPR000792 Transcription regulator LuxR, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSF3
AlphaFold — — full sequence — Viewing
ColabFold KP13_02131
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.002
10 0.001
2 0.0
19 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.12 0.04
2 0.99 0.005