Protein profile

KP13_02134

Phosphonate transport system permease protein

Genome: KpKP13

Gene: AHE46137.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GN83
Export view
Amino acids 290
Annotations 5
Features 26
PDB binders 0
Druggability 0.889

Overview

Basic information about this protein and its source genome.

Accession
KP13_02134
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46137.1
Status
annotated
Amino acids
290
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015416 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). GO:0015716 The directed movement of phosphonates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.17

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.889
Structure A0A0H3GN83
Pocket Pocket 1
P2Rank 0.029
Structure A0A0H3GN83
Pocket Pocket 1
ColabFold model
FPocket 0.876 · Pocket 1
P2Rank 0.069 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 35 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015416 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2).
  • GO:0015716 The directed movement of phosphonates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2).
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
95 278 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
95 278 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
171 258 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
259 277 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
262 284 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
101 126 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
23 49 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
278 290 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
95 277 CDD cd06261 TM_PBP2
95 277 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
26 48 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
19 285 NCBIfam TIGR01097 phosphonate ABC transporter, permease protein PhnE
19 285 InterPro IPR005769 ABC transporter, permease PhnE/PtxC
127 146 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
89 283 Gene3D G3DSA:1.10.3720.10 -
89 283 InterPro IPR035906 MetI-like superfamily
91 278 SUPERFAMILY SSF161098 MetI-like
91 278 InterPro IPR035906 MetI-like superfamily
16 282 PANTHER PTHR30043 PHOSPHONATES TRANSPORT SYSTEM PERMEASE PROTEIN
147 169 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
147 170 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 22 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
50 100 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
104 126 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
114 277 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
114 277 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GN83
AlphaFold — — full sequence — Viewing
ColabFold KP13_02134
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.889
3 0.206

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.71 0.081