Protein profile

KP13_02143

Site-specific recombinase, phage integrase family

Genome: KpKP13

Gene: AHE46149.1 Structure source: AlphaFold + ColabFold UniProt A0A6A8EM33
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Amino acids 406
Annotations 3
Features 16
PDB binders 0
Druggability 0.262

Overview

Basic information about this protein and its source genome.

Accession
KP13_02143
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46149.1
Status
annotated
Amino acids
406
Structure source
AlphaFold + ColabFold
GO
GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
90.31

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.262
Structure A0A6A8EM33
Pocket Pocket 9
P2Rank 0.334
Structure A0A6A8EM33
Pocket Pocket 1
ColabFold model
FPocket 0.205 · Pocket 23
P2Rank 0.365 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 53 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
215 392 ProSiteProfiles PS51898 Tyrosine recombinase domain profile.
215 392 InterPro IPR002104 Integrase, catalytic domain
223 399 CDD cd00801 INT_P4_C
16 101 Pfam PF13356 Arm DNA-binding domain
16 101 InterPro IPR025166 Integrase, DNA-binding domain
111 393 SUPERFAMILY SSF56349 DNA breaking-rejoining enzymes
111 393 InterPro IPR011010 DNA breaking-rejoining enzyme, catalytic core
110 215 Gene3D G3DSA:1.10.150.130 -
110 215 InterPro IPR010998 Integrase/recombinase, N-terminal
13 405 PANTHER PTHR30629 PROPHAGE INTEGRASE
220 383 Pfam PF00589 Phage integrase family
220 383 InterPro IPR002104 Integrase, catalytic domain
216 395 Gene3D G3DSA:1.10.443.10 Intergrase catalytic core
216 395 InterPro IPR013762 Integrase-like, catalytic domain superfamily
14 109 Gene3D G3DSA:3.30.160.390 -
14 109 InterPro IPR038488 Integrase, DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A6A8EM33
AlphaFold — — full sequence — Viewing
ColabFold KP13_02143
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
9 0.262

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.64 0.077
2 1.33 0.015
3 1.29 0.014