Protein profile

KP13_02145

hypothetical protein

Genome: KpKP13

Gene: AHE46153.1 Structure source: AlphaFold + ColabFold UniProt A0A1S0WLD0
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Amino acids 182
Annotations 2
Features 20
PDB binders 0
Druggability 0.294

Overview

Basic information about this protein and its source genome.

Accession
KP13_02145
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46153.1
Status
annotated
Amino acids
182
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
No hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
65.72

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.294
Structure A0A1S0WLD0
Pocket Pocket 16
P2Rank 0.766
Structure A0A1S0WLD0
Pocket Pocket 1
ColabFold model
FPocket 0.728 · Pocket 3
P2Rank 0.22 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 0 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
118 169 Pfam PF00196 Bacterial regulatory proteins, luxR family
118 169 InterPro IPR000792 Transcription regulator LuxR, C-terminal
116 172 SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators
116 172 InterPro IPR016032 Signal transduction response regulator, C-terminal effector
116 173 SMART SM00421 luxrmega5
116 173 InterPro IPR000792 Transcription regulator LuxR, C-terminal
90 178 Gene3D G3DSA:1.10.10.10 -
90 178 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
149 161 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
149 161 InterPro IPR000792 Transcription regulator LuxR, C-terminal
119 133 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
119 133 InterPro IPR000792 Transcription regulator LuxR, C-terminal
133 149 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
133 149 InterPro IPR000792 Transcription regulator LuxR, C-terminal
112 177 ProSiteProfiles PS50043 LuxR-type HTH domain profile.
112 177 InterPro IPR000792 Transcription regulator LuxR, C-terminal
119 163 CDD cd06170 LuxR_C_like
119 163 InterPro IPR000792 Transcription regulator LuxR, C-terminal
133 160 ProSitePatterns PS00622 LuxR-type HTH domain signature.
133 160 InterPro IPR000792 Transcription regulator LuxR, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A1S0WLD0
AlphaFold — — full sequence — Viewing
ColabFold KP13_02145
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
16 0.294
15 0.21

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.34 0.751
2 7.97 0.424
3 3.55 0.131
4 1.41 0.018