Protein profile

KP13_02153

Fimbrial biogenesis outer membrane usher protein

Genome: KpKP13

Gene: AHE46162.1 Structure source: AlphaFold + ColabFold UniProt A0A4S4Z6D4
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Amino acids 852
Annotations 5
Features 22
PDB binders 0
Druggability 0.519

Overview

Basic information about this protein and its source genome.

Accession
KP13_02153
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46162.1
Status
annotated
Amino acids
852
Structure source
AlphaFold + ColabFold
GO
GO:0005515 Binding to a protein. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone. GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
OuterMembrane
ColabFold pLDDT
86.61

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.519
Structure A0A4S4Z6D4
Pocket Pocket 4
P2Rank 0.944
Structure A0A4S4Z6D4
Pocket Pocket 1
ColabFold model
FPocket 0.276 · Pocket 4
P2Rank 0.954 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 51 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005515 Binding to a protein.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone.
  • GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles.
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
664 755 Gene3D G3DSA:2.60.40.2610 Outer membrane usher protein FimD, plug domain
664 755 InterPro IPR042186 Outer membrane usher protein FimD, plug domain
316 326 ProSitePatterns PS01151 Fimbrial biogenesis outer membrane usher protein signature.
316 326 InterPro IPR018030 Fimbrial membrane usher, conserved site
275 362 Gene3D G3DSA:2.60.40.3110 -
199 750 Pfam PF00577 Outer membrane usher protein
199 750 InterPro IPR000015 Outer membrane usher protein
36 156 SUPERFAMILY SSF141729 FimD N-terminal domain-like
36 156 InterPro IPR037224 PapC, N-terminal domain superfamily
33 852 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
12 32 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
761 817 Pfam PF13953 PapC C-terminal domain
761 817 InterPro IPR025949 PapC-like, C-terminal domain
52 170 Gene3D G3DSA:3.10.20.410 -
52 170 InterPro IPR037224 PapC, N-terminal domain superfamily
759 837 Gene3D G3DSA:2.60.40.2070 -
759 837 InterPro IPR043142 PapC-like, C-terminal domain superfamily
14 835 PANTHER PTHR30451 OUTER MEMBRANE USHER PROTEIN
14 835 InterPro IPR000015 Outer membrane usher protein
37 182 Pfam PF13954 PapC N-terminal domain
37 182 InterPro IPR025885 PapC, N-terminal domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A4S4Z6D4
AlphaFold — — full sequence — Viewing
ColabFold KP13_02153
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.435
9 0.274
81 0.215

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 21.13 0.866
2 12.34 0.647
3 5.85 0.286
4 2.97 0.096
5 2.55 0.072