Protein profile

KP13_02154

putative fimbrial protein

Genome: KpKP13

Gene: AHE46163.1 Structure source: AlphaFold + ColabFold UniProt A0A483I2H4
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Amino acids 169
Annotations 3
Features 11
PDB binders 0
Druggability 0.048

Overview

Basic information about this protein and its source genome.

Accession
KP13_02154
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46163.1
Status
annotated
Amino acids
169
Structure source
AlphaFold + ColabFold
GO
GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289 A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709 The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
No hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Extracellular
ColabFold pLDDT
81.64

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.048
Structure A0A483I2H4
Pocket Pocket 6
P2Rank 0.673
Structure A0A483I2H4
Pocket Pocket 1
ColabFold model
FPocket 0.375 · Pocket 1
P2Rank 0.576 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 0 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
  • GO:0009289 A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter.
  • GO:0043709 The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
36 168 Gene3D G3DSA:2.60.40.1090 -
36 168 InterPro IPR036937 Fimbrial-type adhesion domain superfamily
1 15 Phobius SIGNAL_PEPTIDE Signal peptide region
2 10 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
23 168 PANTHER PTHR33420 FIMBRIAL SUBUNIT ELFA-RELATED
1 15 SignalP_EUK SignalP-noTM SignalP-noTM
1 1 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
11 15 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
16 169 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
25 168 SUPERFAMILY SSF49401 Bacterial adhesins
25 168 InterPro IPR008966 Adhesion domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A483I2H4
AlphaFold — — full sequence — Viewing
ColabFold KP13_02154
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.06 0.672
2 1.79 0.033
3 1.6 0.025