Protein profile

KP13_02893

putative signal transduction response regulator

Genome: KpKP13

Gene: AHE46169.1 Structure source: ColabFold
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Amino acids 229
Annotations 3
Features 16
PDB binders 0
Druggability 0.329

Overview

Basic information about this protein and its source genome.

Accession
KP13_02893
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46169.1
Status
annotated
Amino acids
229
Structure source
ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
No hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
80.38

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.329
Structure CB_KP13_02893
Pocket Pocket 9
P2Rank 0.012
Structure CB_KP13_02893
Pocket Pocket 1
ColabFold model
FPocket 0.329 · Pocket 9
P2Rank 0.012 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 0 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
1 66 CDD cd00383 trans_reg_C
1 66 InterPro IPR001867 OmpR/PhoB-type DNA-binding domain
2 66 SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators
2 66 InterPro IPR016032 Signal transduction response regulator, C-terminal effector
1 120 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
3 66 SMART SM00862 Trans_reg_C_3
3 66 InterPro IPR001867 OmpR/PhoB-type DNA-binding domain
140 229 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
117 139 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
4 66 Pfam PF00486 Transcriptional regulatory protein, C terminal
4 66 InterPro IPR001867 OmpR/PhoB-type DNA-binding domain
121 139 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 68 ProSiteProfiles PS51755 OmpR/PhoB-type DNA-binding domain profile.
1 68 InterPro IPR001867 OmpR/PhoB-type DNA-binding domain
1 86 Gene3D G3DSA:1.10.10.10 -
1 86 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold KP13_02893
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
9 0.329

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.16 0.009