Protein profile

KP13_31630

HNH nuclease domain-containing protein

Genome: KpKP13

Gene: AHE46178.1 Structure source: AlphaFold + ColabFold UniProt A0A6A8ENB7
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Amino acids 154
Annotations 3
Features 14
PDB binders 0
Druggability 0.481

Overview

Basic information about this protein and its source genome.

Accession
KP13_31630
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46178.1
Status
annotated
Amino acids
154
Structure source
AlphaFold + ColabFold
GO
GO:0003676 Binding to a nucleic acid. GO:0008270 Binding to a zinc ion (Zn). GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
87.53

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.481
Structure A0A6A8ENB7
Pocket Pocket 8
P2Rank 0.18
Structure A0A6A8ENB7
Pocket Pocket 1
ColabFold model
FPocket 0.774 · Pocket 1
P2Rank 0.242 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 1 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003676 Binding to a nucleic acid.
  • GO:0008270 Binding to a zinc ion (Zn).
  • GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
16 20 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 20 Phobius SIGNAL_PEPTIDE Signal peptide region
100 148 Pfam PF01844 HNH endonuclease
100 148 InterPro IPR002711 HNH endonuclease
86 146 CDD cd00085 HNHc
86 146 InterPro IPR003615 HNH nuclease
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
66 148 PANTHER PTHR41286 HNH NUCLEASE YAJD-RELATED
4 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
87 143 SMART SM00507 HNH_5
87 143 InterPro IPR003615 HNH nuclease
59 154 Gene3D G3DSA:1.10.30.50 -
21 154 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 23 SignalP_EUK SignalP-noTM SignalP-noTM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A6A8ENB7
AlphaFold — — full sequence — Viewing
ColabFold KP13_31630
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.481
7 0.378
3 0.249
2 0.205

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.15 0.107