Protein profile

KP13_02911

Sigma factor-binding protein crl

Genome: KpKP13

Gene: crl AHE46188.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GN42
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Amino acids 132
Annotations 3
Features 6
PDB binders 0
Druggability 0.1

Overview

Basic information about this protein and its source genome.

Accession
KP13_02911
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
crl AHE46188.1
Status
annotated
Amino acids
132
Structure source
AlphaFold + ColabFold
GO
GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
77.87

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.1
Structure A0A0H3GN42
Pocket Pocket 1
P2Rank
Structure A0A0H3GN42
Pocket No pockets
ColabFold model
FPocket 0.107 · Pocket 10
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 94 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
1 126 Pfam PF07417 Sigma factor-binding transcriptional regulator Crl
1 126 InterPro IPR009986 Sigma factor-binding transcriptional regulator Crl
3 128 Hamap MF_01178 Sigma factor-binding protein Crl [crl].
3 128 InterPro IPR009986 Sigma factor-binding transcriptional regulator Crl
1 132 Gene3D G3DSA:3.30.310.230 -
1 132 InterPro IPR038208 Sigma factor-binding protein Crl superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

No pockets are loaded yet for the displayed AlphaFold model AF_A0A0H3GN42 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GN42
AlphaFold — — full sequence — Viewing
ColabFold KP13_02911
ColabFold — — full sequence — Loaded