Protein profile

KP13_02912

putative hydrolase

Genome: KpKP13

Gene: AHE46189.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GIR9
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Amino acids 414
Annotations 3
Features 10
PDB binders 0
Druggability 0.166

Overview

Basic information about this protein and its source genome.

Accession
KP13_02912
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46189.1
Status
annotated
Amino acids
414
Structure source
AlphaFold + ColabFold
EC
3.1.1.1
GO
GO:0016788 Catalysis of the hydrolysis of any ester bond. GO:0106435 Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H+.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
93.83

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.166
Structure A0A0H3GIR9
Pocket Pocket 8
P2Rank 0.441
Structure A0A0H3GIR9
Pocket Pocket 1
ColabFold model
FPocket 0.888 · Pocket 2
P2Rank 0.576 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 108 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0016788 Catalysis of the hydrolysis of any ester bond.
  • GO:0106435 Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H+.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
5 413 Hamap MF_01063 Esterase FrsA [frsA].
5 413 InterPro IPR043423 Esterase FrsA
46 380 PANTHER PTHR22946 UNCHARACTERIZED
16 414 FunFam G3DSA:3.40.50.1820:FF:000022 Esterase FrsA
16 413 Gene3D G3DSA:3.40.50.1820 alpha/beta hydrolase
16 413 InterPro IPR029058 Alpha/Beta hydrolase fold
1 412 Pfam PF06500 Esterase FrsA-like
1 412 InterPro IPR010520 Esterase FrsA-like
46 413 SUPERFAMILY SSF53474 alpha/beta-Hydrolases
46 413 InterPro IPR029058 Alpha/Beta hydrolase fold

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GIR9
AlphaFold — — full sequence — Viewing
ColabFold KP13_02912
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.45 0.259