Protein profile

KP13_02923

Na(+)-translocating NADH-quinone reductase subunit C

Genome: KpKP13

Gene: nqrC AHE46199.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GIR1
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Amino acids 264
Annotations 6
Features 18
PDB binders 0
Druggability 0.79

Overview

Basic information about this protein and its source genome.

Accession
KP13_02923
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
nqrC AHE46199.1
Status
annotated
Amino acids
264
Structure source
AlphaFold + ColabFold
EC
7.2.1.1
GO
GO:0016655 Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0010181 Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0006814 The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
93.91

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.79
Structure A0A0H3GIR1
Pocket Pocket 1
P2Rank 0.387
Structure A0A0H3GIR1
Pocket Pocket 1
ColabFold model
FPocket 0.646 · Pocket 9
P2Rank 0.24 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 101 / 4744 genomes with a hit
Normalized 0.021

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0016655 Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0010181 Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
  • GO:0006814 The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
13 24 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
149 243 Pfam PF04205 FMN-binding domain
149 243 InterPro IPR007329 FMN-binding
7 255 NCBIfam TIGR01938 NADH:ubiquinone reductase (Na(+)-transporting) subunit C
7 255 InterPro IPR010204 Na(+)-translocating NADH-quinone reductase subunit C
8 259 Hamap MF_00427 Na(+)-translocating NADH-quinone reductase subunit C [nqrC].
8 259 InterPro IPR010204 Na(+)-translocating NADH-quinone reductase subunit C
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
30 264 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 12 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 29 Phobius SIGNAL_PEPTIDE Signal peptide region
25 29 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
5 261 PANTHER PTHR37838 NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT C
5 261 InterPro IPR010204 Na(+)-translocating NADH-quinone reductase subunit C
1 262 PIRSF PIRSF009437 NQR-1_subunit_C
1 262 InterPro IPR010204 Na(+)-translocating NADH-quinone reductase subunit C
149 247 SMART SM00900 FMN_bind_2
149 247 InterPro IPR007329 FMN-binding

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GIR1
AlphaFold — — full sequence — Viewing
ColabFold KP13_02923
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.79

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.64 0.337