Overview
Basic information about this protein and its source genome.
- Accession
- KP13_02936
- Gene
- rnhA AHE46208.1
- Status
- annotated
- Amino acids
- 179
- Structure source
- AlphaFold + ColabFold
Target profile
Computed evidence for target prioritization.
- Human off-target
- hit
- Human identity (%)
- 37.324
- Human E-value
- 3.12e-17
- Gut microbiome off-target
- hit
- Essential (DEG)
- Y
- DEG identity (%)
- 90.909
- DEG E-value
- 1.4800000000000001e-105
- Localization
- Unknown
- ColabFold pLDDT
- 89.4
Selected Druggability evidence
AlphaFold / UniProt modelSelected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
Enzyme Commission (EC)
1Gene Ontology (GO)
5- GO:0003676 Binding to a nucleic acid.
- GO:0004523 Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.
- GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
- GO:0000287 Binding to a magnesium (Mg) ion.
- GO:0043137 Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease.
Sequence Features
Domain/signature hits from InterPro and related databases.
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 28 | 165 | CDD | cd09278 | RNase_HI_prokaryote_like |
| 28 | 165 | InterPro | IPR022892 | Ribonuclease HI |
| 25 | 166 | ProSiteProfiles | PS50879 | RNase H type-1 domain profile. |
| 25 | 166 | InterPro | IPR002156 | Ribonuclease H domain |
| 25 | 179 | FunFam | G3DSA:3.30.420.10:FF:000008 | Ribonuclease H |
| 28 | 167 | SUPERFAMILY | SSF53098 | Ribonuclease H-like |
| 28 | 167 | InterPro | IPR012337 | Ribonuclease H-like superfamily |
| 25 | 178 | Gene3D | G3DSA:3.30.420.10 | - |
| 25 | 178 | InterPro | IPR036397 | Ribonuclease H superfamily |
| 27 | 165 | Pfam | PF00075 | RNase H |
| 27 | 165 | InterPro | IPR002156 | Ribonuclease H domain |
| 29 | 169 | PANTHER | PTHR10642 | RIBONUCLEASE H1 |
| 26 | 173 | Hamap | MF_00042 | Ribonuclease H [rnhA]. |
| 26 | 173 | InterPro | IPR022892 | Ribonuclease HI |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Structural evidence
0 + 2Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
AF_W8V4T6
|
AlphaFold | — | — | full sequence | — | Viewing |
|
ColabFold
KP13_02936
|
ColabFold | — | — | full sequence | — | Loaded |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 4 | 0.766 | ||||||
| 7 | 0.487 | ||||||
| 2 | 0.303 | ||||||
| 8 | 0.302 |
Pockets (P2RANK)
Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).
| P2RANK | Sticks | Spheres | Surfaces | Score | Probability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|---|
| 1 | 4.76 | 0.21 | ||||||
| 2 | 1.91 | 0.039 |
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 3 | 0.455 | ||||||
| 1 | 0.267 | ||||||
| 7 | 0.206 |
Pockets (P2RANK)
Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).
| P2RANK | Sticks | Spheres | Surfaces | Score | Probability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|---|
| 1 | 3.55 | 0.131 | ||||||
| 2 | 1.9 | 0.038 | ||||||
| 3 | 1.43 | 0.019 |
Ligand evidence
Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.
Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.
No PDB structure with a co-crystallized ligand found for this exact protein.
Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.
| Ligand | Source crystal | UniProt (homolog) | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|---|
| FLC | O60930 | 189.1 Da LogP -5.25 TPSA 140.6 | ✓ Ro5 | ✓ Clean |
C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O
|
Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL bioactivity data found for this exact protein.
Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
| Ligand | UniProt (homolog) | pchembl | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|---|
| CHEMBL562080 | O60930 | 6.77 | 415.7 Da LogP 3.81 TPSA 103.5 | ✓ Ro5 | ✓ Clean |
O=C(O)c1nc(Cc2c(Br)sc3ccc(Cl)cc23)nc(O)c1O
|
| JTH | O60930 | 6.22 | 180.2 Da LogP 1.58 TPSA 57.5 | ✓ Ro5 | ✓ Clean |
CC(C)C1=CC=C(C(=O)C(=C1)O)O
|
| P1Y | O60930 | 6.05 | 355.1 Da LogP 1.95 TPSA 112.8 | ✓ Ro5 | ✓ Clean |
COc1ccc(cc1Br)Cc2nc(c(c(n2)O)O)C(=O)O
|
Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).
| Ligand | Tanimoto | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|
| ZINC11949639 | 0.552 | 215.1 Da LogP 3.28 TPSA 20.2 | ✓ Ro5 | ✓ Clean |
CC(C)c1ccc(O)c(Br)c1
|
| ZINC95709551 | 0.552 | 262.1 Da LogP 3.12 TPSA 20.2 | ✓ Ro5 | ✓ Clean |
CC(C)c1ccc(I)c(O)c1
|
| ZINC1600645 | 0.533 | 284.4 Da LogP 4.94 TPSA 40.5 | ✓ Ro5 | ✓ Clean |
CC(C)c1ccc(O)c(Cc2cc(C(C)C)ccc2O)c1
|
| ZINC41215043 | 0.531 | 206.3 Da LogP 3.35 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
CC(C)C(=O)c1cc(C(C)C)ccc1O
|
| ZINC391539 | 0.511 | 245.1 Da LogP 2.08 TPSA 46.5 | ✓ Ro5 | ✓ Clean |
COc1ccc(CC(=O)O)cc1Br
|
| ZINC13420409 | 0.500 | 367.2 Da LogP 3.74 TPSA 65.0 | ✓ Ro5 | ✓ Clean |
COc1ccc(COc2ccc(C(=O)O)cc2OC)cc1Br
|
| ZINC238169092 | 0.500 | 207.3 Da LogP 3.17 TPSA 46.2 | ✓ Ro5 | Alert |
CC(C)c1ccc(O)c([C@H](N)C(C)C)c1
|
| ZINC238169758 | 0.500 | 207.3 Da LogP 3.17 TPSA 46.2 | ✓ Ro5 | Alert |
CC(C)c1ccc(O)c([C@@H](N)C(C)C)c1
|
| ZINC52068548 | 0.500 | 220.3 Da LogP 3.74 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
CC(C)c1ccc(O)c(C(=O)C(C)(C)C)c1
|
PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.