Protein profile

KP13_31635

S-adenosyl-L-methionine-dependent methyltransferase

Genome: KpKP13

Gene: AHE46209.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GJU4
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Amino acids 242
Annotations 3
Features 6
PDB binders 0
Druggability 0.547

Overview

Basic information about this protein and its source genome.

Accession
KP13_31635
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46209.1
Status
annotated
Amino acids
242
Structure source
AlphaFold + ColabFold
GO
GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0008757 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. GO:0032259 The process in which a methyl group is covalently attached to a molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
84.2

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.547
Structure A0A0H3GJU4
Pocket Pocket 2
P2Rank 0.175
Structure A0A0H3GJU4
Pocket Pocket 1
ColabFold model
FPocket 0.703 · Pocket 6
P2Rank 0.617 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 106 / 4744 genomes with a hit
Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.
  • GO:0008757 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
  • GO:0032259 The process in which a methyl group is covalently attached to a molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
75 126 Pfam PF08241 Methyltransferase domain
75 126 InterPro IPR013216 Methyltransferase type 11
54 180 Gene3D G3DSA:3.40.50.150 Vaccinia Virus protein VP39
54 180 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
56 208 SUPERFAMILY SSF53335 S-adenosyl-L-methionine-dependent methyltransferases
56 208 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GJU4
AlphaFold — — full sequence — Viewing
ColabFold KP13_31635
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.547
1 0.037
7 0.014
10 0.002

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.8 0.175
2 3.69 0.113
3 3.4 0.097
4 2.02 0.036
5 1.62 0.021