Protein profile

KP13_01782

Protein rcsF

Genome: KpKP13

Gene: AHE46222.1 rcsF Structure source: AlphaFold + ColabFold UniProt A0A0H3GN11
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Amino acids 118
Annotations 3
Features 8
PDB binders 0
Druggability 0.445

Overview

Basic information about this protein and its source genome.

Accession
KP13_01782
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46222.1 rcsF
Status
annotated
Amino acids
118
Structure source
AlphaFold + ColabFold
GO
GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0035556 The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. GO:0031241 The leaflet of a outer cell membrane that faces the periplasm, including any protein embedded in, attached to, or peripherally associated with it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
OuterMembrane
ColabFold pLDDT
85.56

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.445
Structure A0A0H3GN11
Pocket Pocket 3
P2Rank
Structure A0A0H3GN11
Pocket No pockets
ColabFold model
FPocket 0.221 · Pocket 4
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 92 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0035556 The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
  • GO:0031241 The leaflet of a outer cell membrane that faces the periplasm, including any protein embedded in, attached to, or peripherally associated with it.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
1 19 MobiDBLite mobidb-lite consensus disorder prediction
1 72 MobiDBLite mobidb-lite consensus disorder prediction
9 116 Pfam PF16358 RcsF lipoprotein
9 116 InterPro IPR030852 Outer membrane lipoprotein RcsF
55 72 MobiDBLite mobidb-lite consensus disorder prediction
1 117 Hamap MF_00976 Outer membrane lipoprotein RcsF [rcsF].
1 117 InterPro IPR030852 Outer membrane lipoprotein RcsF
14 118 Gene3D G3DSA:3.30.110.70 Hypothetical protein apc22750. Chain B

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GN11
AlphaFold — — full sequence — Viewing
ColabFold KP13_01782
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.445