Protein profile

KP13_01783

hypothetical protein

Genome: KpKP13

Gene: AHE46223.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GIP0
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Amino acids 235
Annotations 4
Features 21
PDB binders 0
Druggability 0.202

Overview

Basic information about this protein and its source genome.

Accession
KP13_01783
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46223.1
Status
annotated
Amino acids
235
Structure source
AlphaFold + ColabFold
GO
GO:0003723 Binding to an RNA molecule or a portion thereof. GO:0089715 Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing N6-threonylcarbamoyladenosine at position 37 = S-adenosyl-L-homocysteine + tRNA containing N6-methylthreonylcarbamoyladenosine at position 37. GO:0032259 The process in which a methyl group is covalently attached to a molecule. GO:0008033 The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
40.385
Human E-value
8.29e-19
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
49.153
DEG E-value
9.84e-87
Localization
Cytoplasmic
ColabFold pLDDT
93.97

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.202
Structure A0A0H3GIP0
Pocket Pocket 12
P2Rank 0.378
Structure A0A0H3GIP0
Pocket Pocket 1
ColabFold model
FPocket 0.742 · Pocket 1
P2Rank 0.458 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 143 / 4744 genomes with a hit
Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0003723 Binding to an RNA molecule or a portion thereof.
  • GO:0089715 Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing N6-threonylcarbamoyladenosine at position 37 = S-adenosyl-L-homocysteine + tRNA containing N6-methylthreonylcarbamoyladenosine at position 37.
  • GO:0032259 The process in which a methyl group is covalently attached to a molecule.
  • GO:0008033 The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
4 226 PANTHER PTHR12818 UNCHARACTERIZED
4 226 InterPro IPR040372 YaeB-like
22 142 Pfam PF01980 tRNA-methyltransferase O
22 142 InterPro IPR023370 TrmO-like, N-terminal domain
160 223 Pfam PF18389 TrmO C-terminal domain
160 223 InterPro IPR041369 TrmO, C-terminal
9 138 CDD cd09281 UPF0066
9 138 InterPro IPR023370 TrmO-like, N-terminal domain
87 98 ProSitePatterns PS01318 TsaA-like domain signature.
87 98 InterPro IPR023368 Uncharacterised protein family UPF0066, conserved site
141 231 FunFam G3DSA:3.30.2310.10:FF:000001 tRNA (N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase TrmO
1 140 Gene3D G3DSA:2.40.30.70 -
1 140 InterPro IPR036414 YaeB, N-terminal domain superfamily
6 147 ProSiteProfiles PS51668 TsaA-like domain profile.
6 147 InterPro IPR023370 TrmO-like, N-terminal domain
2 229 SUPERFAMILY SSF118196 YaeB-like
2 229 InterPro IPR036413 YaeB-like superfamily
1 149 NCBIfam TIGR00104 tRNA (N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase TrmO
1 149 InterPro IPR023370 TrmO-like, N-terminal domain
141 230 Gene3D G3DSA:3.30.2310.10 -
1 140 FunFam G3DSA:2.40.30.70:FF:000001 tRNA (N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase TrmO

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GIP0
AlphaFold — — full sequence — Viewing
ColabFold KP13_01783
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.202

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.02 0.297
2 1.74 0.031