Protein profile

KP13_01787

peptidyl-tRNA hydrolase domain-containing protein

Genome: KpKP13

Gene: AHE46227.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GN06
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Amino acids 137
Annotations 8
Features 11
PDB binders 0
Druggability 0.212

Overview

Basic information about this protein and its source genome.

Accession
KP13_01787
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46227.1
Status
annotated
Amino acids
137
Structure source
AlphaFold + ColabFold
EC
3.1.1.29
GO
GO:0003747 Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. GO:0006415 The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004045 Catalysis of the reaction: an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H+. GO:0043022 Binding to a ribosome. GO:0006417 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
89.55

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.212
Structure A0A0H3GN06
Pocket Pocket 6
P2Rank 0.002
Structure A0A0H3GN06
Pocket Pocket 1
ColabFold model
FPocket 0.114 · Pocket 2
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 109 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 7 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

7
  • GO:0003747 Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.
  • GO:0006415 The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0004045 Catalysis of the reaction: an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H+.
  • GO:0043022 Binding to a ribosome.
  • GO:0006417 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
  • GO:0072344 A process of cytosolic translational elongation that takes place when a cytosolic ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
103 123 MobiDBLite mobidb-lite consensus disorder prediction
1 137 FunFam G3DSA:3.30.160.20:FF:000029 Peptidyl-tRNA hydrolase YaeJ
1 136 PANTHER PTHR47814 PEPTIDYL-TRNA HYDROLASE ARFB
8 132 Pfam PF00472 RF-1 domain
8 132 InterPro IPR000352 Peptide chain release factor class I
8 108 SUPERFAMILY SSF75620 Release factor
8 108 InterPro IPR045853 Peptide chain release factor class I superfamily
21 37 ProSitePatterns PS00745 Prokaryotic-type class I peptide chain release factors signature.
21 37 InterPro IPR000352 Peptide chain release factor class I
1 137 Gene3D G3DSA:3.30.160.20 -
103 137 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GN06
AlphaFold — — full sequence — Viewing
ColabFold KP13_01787
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.212