Protein profile

KP13_01792

Glyoxalase domain-containing protein

Genome: KpKP13

Gene: AHE46232.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GNK5
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Amino acids 129
Annotations 1
Features 12
PDB binders 0
Druggability 0.238

Overview

Basic information about this protein and its source genome.

Accession
KP13_01792
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46232.1
Status
annotated
Amino acids
129
Structure source
AlphaFold + ColabFold
GO
GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
97.58

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.238
Structure A0A0H3GNK5
Pocket Pocket 4
P2Rank 0.124
Structure A0A0H3GNK5
Pocket Pocket 1
ColabFold model
FPocket 0.953 · Pocket 3
P2Rank 0.181 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 387 / 4744 genomes with a hit
Normalized 0.082

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
9 128 Gene3D G3DSA:3.10.180.10 -
9 128 InterPro IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
7 126 PANTHER PTHR36113 LYASE, PUTATIVE-RELATED-RELATED
6 129 ProSiteProfiles PS51819 Vicinal oxygen chelate (VOC) domain profile.
6 129 InterPro IPR037523 Vicinal oxygen chelate (VOC) domain
7 126 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
7 126 InterPro IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain
126 129 Coils Coil Coil
3 128 SUPERFAMILY SSF54593 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
3 128 InterPro IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
5 128 CDD cd08352 VOC_Bs_YwkD_like
5 128 InterPro IPR037478 YwkD-like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GNK5
AlphaFold — — full sequence — Viewing
ColabFold KP13_01792
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.238

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.63 0.136
2 0.98 0.005