Protein profile

KP13_01797

Lipid-A-disaccharide synthase

Genome: KpKP13

Gene: lpxB AHE46237.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GNK2
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Amino acids 383
Annotations 5
Features 10
PDB binders 0
Druggability 0.92

Overview

Basic information about this protein and its source genome.

Accession
KP13_01797
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
lpxB AHE46237.1
Status
annotated
Amino acids
383
Structure source
AlphaFold + ColabFold
EC
2.4.1.182
GO
GO:0008915 Catalysis of the reaction: a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + UDP + H+. GO:0009245 The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005543 Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
91.623
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.55

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.92
Structure A0A0H3GNK2
Pocket Pocket 4
P2Rank 0.359
Structure A0A0H3GNK2
Pocket Pocket 1
ColabFold model
FPocket 0.525 · Pocket 16
P2Rank 0.407 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 162 / 4744 genomes with a hit
Normalized 0.034

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0008915 Catalysis of the reaction: a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + UDP + H+.
  • GO:0009245 The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005543 Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
6 382 Hamap MF_00392 Lipid-A-disaccharide synthase [lpxB].
6 382 InterPro IPR003835 Glycosyl transferase, family 19
1 380 NCBIfam TIGR00215 lipid-A-disaccharide synthase
1 380 InterPro IPR003835 Glycosyl transferase, family 19
9 378 SUPERFAMILY SSF53756 UDP-Glycosyltransferase/glycogen phosphorylase
9 377 Pfam PF02684 Lipid-A-disaccharide synthetase
9 377 InterPro IPR003835 Glycosyl transferase, family 19
36 293 CDD cd01635 Glycosyltransferase_GTB-type
2 383 PANTHER PTHR30372 LIPID-A-DISACCHARIDE SYNTHASE
2 383 InterPro IPR003835 Glycosyl transferase, family 19

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GNK2
AlphaFold — — full sequence — Viewing
ColabFold KP13_01797
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.92

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.97 0.294
2 4.88 0.219
3 4.12 0.166
4 2.95 0.095
5 1.3 0.014