Protein profile

KP13_01801

Chaperone protein skp

Genome: KpKP13

Gene: skp AHE46241.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GJP1
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Amino acids 161
Annotations 4
Features 19
PDB binders 0
Druggability 0.193

Overview

Basic information about this protein and its source genome.

Accession
KP13_01801
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
skp AHE46241.1
Status
annotated
Amino acids
161
Structure source
AlphaFold + ColabFold
GO
GO:0051082 Binding to an unfolded protein. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0050821 Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
90.062
DEG E-value
5.25e-94
Localization
Periplasmic
ColabFold pLDDT
90.8

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.193
Structure A0A0H3GJP1
Pocket Pocket 2
P2Rank 0.004
Structure A0A0H3GJP1
Pocket Pocket 1
ColabFold model
FPocket 0.311 · Pocket 2
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 91 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0051082 Binding to an unfolded protein.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
  • GO:0050821 Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
16 20 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 20 Phobius SIGNAL_PEPTIDE Signal peptide region
1 20 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
21 161 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
23 159 Pfam PF03938 Outer membrane protein (OmpH-like)
23 159 InterPro IPR005632 Chaperone protein Skp
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 20 SignalP_EUK SignalP-noTM SignalP-noTM
10 161 SMART SM00935 OmpH_2
10 161 InterPro IPR005632 Chaperone protein Skp
1 161 PIRSF PIRSF002094 OMP26_Skp
1 161 InterPro IPR005632 Chaperone protein Skp
19 161 Gene3D G3DSA:3.30.910.20 Skp domain
19 161 InterPro IPR024930 Skp domain superfamily
1 161 PANTHER PTHR35089 CHAPERONE PROTEIN SKP
4 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
19 161 FunFam G3DSA:3.30.910.20:FF:000001 Molecular chaperone Skp
20 160 SUPERFAMILY SSF111384 OmpH-like
20 160 InterPro IPR024930 Skp domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GJP1
AlphaFold — — full sequence — Viewing
ColabFold KP13_01801
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer