Protein profile

KP13_01803

Regulator of sigma E protease

Genome: KpKP13

Gene: AHE46243.1 rseP Structure source: AlphaFold + ColabFold UniProt A0A0H3GMW3
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Amino acids 450
Annotations 7
Features 43
PDB binders 0
Druggability 0.911

Overview

Basic information about this protein and its source genome.

Accession
KP13_01803
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46243.1 rseP
Status
annotated
Amino acids
450
Structure source
AlphaFold + ColabFold
EC
3.4.24.-
GO
GO:0004222 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0005515 Binding to a protein. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
88.667
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
94.2

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.911
Structure A0A0H3GMW3
Pocket Pocket 28
P2Rank 0.94
Structure A0A0H3GMW3
Pocket Pocket 1
ColabFold model
FPocket 0.529 · Pocket 23
P2Rank 0.981 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 141 / 4744 genomes with a hit
Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0004222 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
  • GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
  • GO:0005515 Binding to a protein.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

43 records
Show feature table
Start End DB Term Name
56 73 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
397 425 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
196 290 SUPERFAMILY SSF50156 PDZ domain-like
196 290 InterPro IPR036034 PDZ superfamily
221 309 FunFam G3DSA:2.30.42.10:FF:000095 Zinc metalloprotease
224 438 Pfam PF02163 Peptidase family M50
224 438 InterPro IPR008915 Peptidase M50
10 182 Pfam PF02163 Peptidase family M50
10 182 InterPro IPR008915 Peptidase M50
3 450 NCBIfam TIGR00054 RIP metalloprotease RseP
3 450 InterPro IPR004387 Peptidase M50, putative membrane-associated zinc metallopeptidase
98 120 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
445 450 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
426 444 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
220 309 Gene3D G3DSA:2.30.42.10 -
220 309 InterPro IPR036034 PDZ superfamily
120 375 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
8 120 CDD cd06163 S2P-M50_PDZ_RseP-like
74 97 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
199 291 ProSiteProfiles PS50106 PDZ domain profile.
199 291 InterPro IPR001478 PDZ domain
211 280 SMART SM00228 pdz_new
211 280 InterPro IPR001478 PDZ domain
115 185 SMART SM00228 pdz_new
115 185 InterPro IPR001478 PDZ domain
6 29 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
212 289 CDD cd00989 PDZ_metalloprotease
87 181 SUPERFAMILY SSF50156 PDZ domain-like
87 181 InterPro IPR036034 PDZ superfamily
30 55 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
98 119 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
376 398 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 21 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
216 450 PANTHER PTHR42837 REGULATOR OF SIGMA-E PROTEASE RSEP
216 450 InterPro IPR004387 Peptidase M50, putative membrane-associated zinc metallopeptidase
126 219 Gene3D G3DSA:2.30.42.10 -
126 219 InterPro IPR036034 PDZ superfamily
227 278 Pfam PF17820 PDZ domain
227 278 InterPro IPR041489 PDZ domain 6
116 189 CDD cd00989 PDZ_metalloprotease
426 445 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
376 396 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GMW3
AlphaFold — — full sequence — Viewing
ColabFold KP13_01803
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
28 0.911
11 0.9

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 18.26 0.819
2 7.98 0.424
3 5.69 0.275
4 3.46 0.125
5 2.91 0.093