Protein profile

KP13_01809

Uridylate kinase

Genome: KpKP13

Gene: pyrH AHE46249.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GMV8
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Amino acids 241
Annotations 9
Features 16
PDB binders 1
Druggability 0.161

Overview

Basic information about this protein and its source genome.

Accession
KP13_01809
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
pyrH AHE46249.1
Status
annotated
Amino acids
241
Structure source
AlphaFold + ColabFold
EC
2.7.4.22
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009041 OBSOLETE. Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP. GO:0006221 The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0033862 Catalysis of the reaction: ATP + UMP = ADP + UDP. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
99.17
DEG E-value
4.62e-178
Localization
Cytoplasmic
ColabFold pLDDT
94.94

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.161
Structure A0A0H3GMV8
Pocket Pocket 13
P2Rank 0.788
Structure A0A0H3GMV8
Pocket Pocket 1
ColabFold model
FPocket 0.391 · Pocket 3
P2Rank 0.734 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 1458 / 4744 genomes with a hit
Normalized 0.307

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 8 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

8
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0009041 OBSOLETE. Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP.
  • GO:0006221 The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
  • GO:0033862 Catalysis of the reaction: ATP + UMP = ADP + UDP.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0044210 The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components.
  • GO:0006225 The chemical reactions and pathways resulting in the formation of UDP, uridine (5'-)diphosphate.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
3 241 FunFam G3DSA:3.40.1160.10:FF:000001 Uridylate kinase
4 240 PANTHER PTHR42833 URIDYLATE KINASE
9 240 NCBIfam TIGR02075 UMP kinase
9 240 InterPro IPR015963 Uridylate kinase, bacteria
4 241 PIRSF PIRSF005650 Uridylate_kin
4 241 InterPro IPR011817 Uridylate kinase
7 240 SUPERFAMILY SSF53633 Carbamate kinase-like
7 240 InterPro IPR036393 Acetylglutamate kinase-like superfamily
10 240 CDD cd04254 AAK_UMPK-PyrH-Ec
10 240 InterPro IPR015963 Uridylate kinase, bacteria
1 241 Gene3D G3DSA:3.40.1160.10 -
1 241 InterPro IPR036393 Acetylglutamate kinase-like superfamily
10 219 Pfam PF00696 Amino acid kinase family
10 219 InterPro IPR001048 Aspartate/glutamate/uridylate kinase
7 240 Hamap MF_01220_B Uridylate kinase [pyrH].
7 240 InterPro IPR015963 Uridylate kinase, bacteria

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GMV8
AlphaFold — — full sequence — Viewing
ColabFold KP13_01809
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.56 0.567
2 2.99 0.097

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
ANP
2BRI
Q8U122 506.2 Da LogP -2.06 TPSA 281.9 3 viol. ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.