Protein profile

KP13_01813

PII uridylyl-transferase

Genome: KpKP13

Gene: glnD AHE46253.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GNI7
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Amino acids 867
Annotations 6
Features 41
PDB binders 0
Druggability 0.586

Overview

Basic information about this protein and its source genome.

Accession
KP13_01813
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
glnD AHE46253.1
Status
annotated
Amino acids
867
Structure source
AlphaFold + ColabFold
GO
GO:0016779 Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). GO:0008773 Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII). GO:0006807 OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. GO:0008893 Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP + H+. GO:0008081 Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. GO:0006808 Any process that modulates the frequency, rate or extent of nitrogen utilization.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
88.786
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
91.85

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.586
Structure A0A0H3GNI7
Pocket Pocket 9
P2Rank 0.823
Structure A0A0H3GNI7
Pocket Pocket 1
ColabFold model
FPocket 0.468 · Pocket 1
P2Rank 0.845 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 122 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0016779 Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).
  • GO:0008773 Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII).
  • GO:0006807 OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.
  • GO:0008893 Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP + H+.
  • GO:0008081 Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.
  • GO:0006808 Any process that modulates the frequency, rate or extent of nitrogen utilization.

Sequence Features

Domain/signature hits from InterPro and related databases.

41 records
Show feature table
Start End DB Term Name
3 866 PIRSF PIRSF006288 PII_uridyltransf
3 866 InterPro IPR010043 Bifunctional uridylyltransferase/uridylyl-removing enzyme
32 861 NCBIfam TIGR01693 [protein-PII] uridylyltransferase
32 861 InterPro IPR010043 Bifunctional uridylyltransferase/uridylyl-removing enzyme
1 867 Hamap MF_00277 Bifunctional uridylyltransferase/uridylyl-removing enzyme [glnD].
1 867 InterPro IPR010043 Bifunctional uridylyltransferase/uridylyl-removing enzyme
682 755 SUPERFAMILY SSF55021 ACT-like
682 755 InterPro IPR045865 ACT-like domain
792 850 SUPERFAMILY SSF55021 ACT-like
792 850 InterPro IPR045865 ACT-like domain
686 761 ProSiteProfiles PS51671 ACT domain profile.
686 761 InterPro IPR002912 ACT domain
443 595 CDD cd00077 HDc
443 595 InterPro IPR003607 HD/PDEase domain
445 578 Pfam PF01966 HD domain
445 578 InterPro IPR006674 HD domain
684 755 CDD cd04900 ACT_UUR-like_1
794 851 Pfam PF01842 ACT domain
794 851 InterPro IPR002912 ACT domain
686 739 Pfam PF01842 ACT domain
686 739 InterPro IPR002912 ACT domain
8 865 PANTHER PTHR47320 BIFUNCTIONAL URIDYLYLTRANSFERASE/URIDYLYL-REMOVING ENZYME
8 865 InterPro IPR010043 Bifunctional uridylyltransferase/uridylyl-removing enzyme
57 124 Pfam PF01909 Nucleotidyltransferase domain
57 124 InterPro IPR002934 Polymerase, nucleotidyl transferase domain
434 576 FunFam G3DSA:1.10.3210.10:FF:000005 Bifunctional uridylyltransferase/uridylyl-removing enzyme
189 305 SUPERFAMILY SSF81593 Nucleotidyltransferase substrate binding subunit/domain
794 861 CDD cd04899 ACT_ACR-UUR-like_2
24 160 CDD cd05401 NT_GlnE_GlnD_like
170 308 Pfam PF08335 GlnD PII-uridylyltransferase
170 308 InterPro IPR013546 PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
434 576 Gene3D G3DSA:1.10.3210.10 Hypothetical protein af1432
793 867 ProSiteProfiles PS51671 ACT domain profile.
793 867 InterPro IPR002912 ACT domain
434 577 SUPERFAMILY SSF109604 HD-domain/PDEase-like
35 165 SUPERFAMILY SSF81301 Nucleotidyltransferase
35 165 InterPro IPR043519 Nucleotidyltransferase superfamily
441 588 SMART SM00471 hd_13
441 588 InterPro IPR003607 HD/PDEase domain
445 567 ProSiteProfiles PS51831 HD domain profile.
445 567 InterPro IPR006674 HD domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GNI7
AlphaFold — — full sequence — Viewing
ColabFold KP13_01813
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.481
1 0.098
18 0.0
37 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 22.19 0.823
2 20.16 0.789
3 18.58 0.755
4 11.4 0.526
5 10.53 0.486