Protein profile

KP13_01822

Iron--sulfur cluster insertion protein erpA

Genome: KpKP13

Gene: AHE46262.1 erpA Structure source: AlphaFold + ColabFold UniProt A0A0H3GJM2
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Amino acids 114
Annotations 6
Features 14
PDB binders 1
Druggability 0.63

Overview

Basic information about this protein and its source genome.

Accession
KP13_01822
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46262.1 erpA
Status
annotated
Amino acids
114
Structure source
AlphaFold + ColabFold
GO
GO:0016226 The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0051537 Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0005506 Binding to an iron (Fe) ion.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
45.783
Human E-value
1.13e-19
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
97.368
DEG E-value
4.65e-80
Localization
Cytoplasmic
ColabFold pLDDT
72.68

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.63
Structure A0A0H3GJM2
Pocket Pocket 9
P2Rank 0.026
Structure A0A0H3GJM2
Pocket Pocket 1
ColabFold model
FPocket 0.463 · Pocket 4
P2Rank 0.024 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 266 / 4744 genomes with a hit
Normalized 0.056

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0016226 The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
  • GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0051537 Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
  • GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
  • GO:0005506 Binding to an iron (Fe) ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
8 103 SUPERFAMILY SSF89360 HesB-like domain
8 103 InterPro IPR035903 HesB-like domain superfamily
9 114 FunFam G3DSA:2.60.300.12:FF:000002 Iron-sulfur cluster insertion protein ErpA
9 109 Pfam PF01521 Iron-sulphur cluster biosynthesis
9 109 InterPro IPR000361 FeS cluster biogenesis
7 114 PANTHER PTHR43011 IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL
95 112 ProSitePatterns PS01152 Hypothetical hesB/yadR/yfhF family signature.
95 112 InterPro IPR017870 FeS cluster insertion, C-terminal, conserved site
10 114 NCBIfam TIGR00049 iron-sulfur cluster assembly accessory protein
10 114 InterPro IPR016092 FeS cluster insertion protein
1 114 Hamap MF_01380 Iron-sulfur cluster insertion protein ErpA [erpA].
1 114 InterPro IPR023063 FeS cluster insertion protein ErpA
9 114 Gene3D G3DSA:2.60.300.12 -
9 114 InterPro IPR035903 HesB-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GJM2
AlphaFold — — full sequence — Viewing
ColabFold KP13_01822
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.003
3 0.001
1 0.0
6 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.74 0.026

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

2 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
FES
1X0G
Q8DLM0 175.8 Da LogP 1.29 TPSA 0.0 ✓ Ro5 ✓ Clean S1[Fe]S[Fe]1

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.