Protein profile

KP13_01826

Iron(3+)-hydroxamate-binding protein fhuD

Genome: KpKP13

Gene: fhuD AHE46266.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GS11
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Amino acids 296
Annotations 2
Features 22
PDB binders 4
Druggability 0.546

Overview

Basic information about this protein and its source genome.

Accession
KP13_01826
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
fhuD AHE46266.1
Status
annotated
Amino acids
296
Structure source
AlphaFold + ColabFold
GO
GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:1901678 The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Periplasmic
ColabFold pLDDT
92.38

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.546
Structure A0A0H3GS11
Pocket Pocket 2
P2Rank 0.611
Structure A0A0H3GS11
Pocket Pocket 1
ColabFold model
FPocket 0.318 · Pocket 1
P2Rank 0.653 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 92 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
  • GO:1901678 The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
1 30 Phobius SIGNAL_PEPTIDE Signal peptide region
55 73 PRINTS PR01715 Ferrichrome-binding periplasmic protein signature
236 253 PRINTS PR01715 Ferrichrome-binding periplasmic protein signature
86 101 PRINTS PR01715 Ferrichrome-binding periplasmic protein signature
273 286 PRINTS PR01715 Ferrichrome-binding periplasmic protein signature
184 199 PRINTS PR01715 Ferrichrome-binding periplasmic protein signature
208 226 PRINTS PR01715 Ferrichrome-binding periplasmic protein signature
37 296 ProSiteProfiles PS50983 Iron siderophore/cobalamin periplasmic-binding domain profile.
37 296 InterPro IPR002491 ABC transporter periplasmic binding domain
1 30 SignalP_GRAM_NEGATIVE SignalP-TM SignalP-TM
24 30 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
31 121 Gene3D G3DSA:3.40.50.1980 Nitrogenase molybdenum iron protein domain
34 285 CDD cd01146 FhuD
1 11 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
31 121 FunFam G3DSA:3.40.50.1980:FF:000016 Fe(3+)-hydroxamate ABC transporter substrate-binding protein FhuD
123 292 Gene3D G3DSA:3.40.50.1980 Nitrogenase molybdenum iron protein domain
28 290 PANTHER PTHR30532 IRON III DICITRATE-BINDING PERIPLASMIC PROTEIN
38 270 Pfam PF01497 Periplasmic binding protein
38 270 InterPro IPR002491 ABC transporter periplasmic binding domain
12 23 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
31 296 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
33 290 SUPERFAMILY SSF53807 Helical backbone metal receptor

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GS11
AlphaFold — — full sequence — Viewing
ColabFold KP13_01826
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.013
17 0.003
1 0.002
7 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.68 0.611

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

54 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
GCR
1EFD
P07822 — — — CC1=O[Ga]2345O=C(N(O2)CCC[C@H]6C(=O)NCC(=O)N[C@…
OPV
6MFL
Q76HK0 346.3 Da LogP 0.32 TPSA 127.8 ✓ Ro5 Alert C[C@H]1[C@@H](C(=O)N(O1)CCc2c[nH]cn2)NC(=O)c3cc…
PE3
6ALL
Q81L65 634.8 Da LogP -0.81 TPSA 160.5 2 viol. ✓ Clean C(COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)O
SF8
3LHS
A0A0H3K9U6 480.4 Da LogP -3.19 TPSA 285.2 1 viol. ✓ Clean C(C[C@H](C(=O)O)NC(=O)C[C@@](CC(=O)O)(C(=O)O)O)…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.