Protein profile

KP13_05655

Pullulanase secretion protein pulS

Genome: KpKP13

Gene: AHE46272.1 pulS Structure source: Experimental + AlphaFold + ColabFold UniProt A0A0H3GNG8
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Amino acids 133
Annotations 1
Features 13
PDB binders 0
Druggability 0.542

Overview

Basic information about this protein and its source genome.

Accession
KP13_05655
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46272.1 pulS
Status
annotated
Amino acids
133
Structure source
Experimental + AlphaFold + ColabFold
GO
GO:0006886 The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
OuterMembrane
ColabFold pLDDT
82.44

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.542
Structure A0A0H3GNG8
Pocket Pocket 1
P2Rank 0.032
Structure A0A0H3GNG8
Pocket Pocket 1
ColabFold model
FPocket 0.197 · Pocket 1
P2Rank 0.068 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 7 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0006886 The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
24 127 Pfam PF09691 Type II secretion system pilotin lipoprotein (PulS_OutS)
24 127 InterPro IPR019114 Chaperone lipoprotein, PulS/OutS-like
39 131 Gene3D G3DSA:1.20.58.1630 Chaperone lipoprotein PulS/OutS
39 131 InterPro IPR038432 PulS/OutS-like superfamily
14 24 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 29 Phobius SIGNAL_PEPTIDE Signal peptide region
25 29 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 13 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 26 SignalP_EUK SignalP-noTM SignalP-noTM
18 129 NCBIfam TIGR01004 type II secretion system pilot lipoprotein GspS
18 129 InterPro IPR005699 Chaperone lipoprotein, PulS/OutS
30 133 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 32 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 6HCG
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Viewing
AlphaFold AF_A0A0H3GNG8
AlphaFold — — full sequence — Loaded
ColabFold KP13_05655
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 17.02 0.794
2 15.72 0.76
3 15.26 0.75
4 14.74 0.733
5 14.34 0.719