Protein profile

KP13_01840

General secretion pathway protein G

Genome: KpKP13

Gene: AHE46280.1 pulG Structure source: AlphaFold + ColabFold UniProt A0A0H3GNF8
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Amino acids 144
Annotations 3
Features 22
PDB binders 1
Druggability 0.146

Overview

Basic information about this protein and its source genome.

Accession
KP13_01840
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46280.1 pulG
Status
annotated
Amino acids
144
Structure source
AlphaFold + ColabFold
GO
GO:0015627 A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
88.73

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.146
Structure A0A0H3GNF8
Pocket Pocket 8
P2Rank 0.038
Structure A0A0H3GNF8
Pocket Pocket 1
ColabFold model
FPocket 0.898 · Pocket 4
P2Rank 0.093 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 89 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0015627 A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex.
  • GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
4 73 PANTHER PTHR30093 GENERAL SECRETION PATHWAY PROTEIN G
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
9 139 NCBIfam TIGR01710 type II secretion system major pseudopilin GspG
9 139 InterPro IPR010054 Type II secretion system protein GspG
24 139 Gene3D G3DSA:3.30.700.10 Glycoprotein, Type 4 Pilin
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
5 30 Pfam PF07963 Prokaryotic N-terminal methylation motif
5 30 InterPro IPR012902 Prokaryotic N-terminal methylation site
9 29 ProSitePatterns PS00409 Prokaryotic N-terminal methylation site.
9 29 InterPro IPR012902 Prokaryotic N-terminal methylation site
33 139 Pfam PF08334 Type II secretion system (T2SS), protein G
33 139 InterPro IPR013545 Type II secretion system protein GspG, C-terminal
12 35 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
36 140 SUPERFAMILY SSF54523 Pili subunits
36 140 InterPro IPR045584 Pilin-like
36 144 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
46 64 PRINTS PR00813 Bacterial general secretion pathway protein G signature
46 64 InterPro IPR000983 Bacterial general secretion pathway protein G-type pilin
10 35 PRINTS PR00813 Bacterial general secretion pathway protein G signature
10 35 InterPro IPR000983 Bacterial general secretion pathway protein G-type pilin
8 30 NCBIfam TIGR02532 prepilin-type N-terminal cleavage/methylation domain
8 30 InterPro IPR012902 Prokaryotic N-terminal methylation site

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GNF8
AlphaFold — — full sequence — Viewing
ColabFold KP13_01840
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.28 0.013

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

16 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
NHE
3G20
Q7BSV8 207.3 Da LogP 0.80 TPSA 66.4 ✓ Ro5 ✓ Clean C1CCC(CC1)NCCS(=O)(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.