Protein profile

KP13_01841

General secretion pathway protein H

Genome: KpKP13

Gene: AHE46281.1 pulH Structure source: AlphaFold + ColabFold UniProt A0A0H3GMS3
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Amino acids 171
Annotations 3
Features 24
PDB binders 0
Druggability 0.372

Overview

Basic information about this protein and its source genome.

Accession
KP13_01841
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46281.1 pulH
Status
annotated
Amino acids
171
Structure source
AlphaFold + ColabFold
GO
GO:0015627 A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
87.18

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.372
Structure A0A0H3GMS3
Pocket Pocket 13
P2Rank
Structure A0A0H3GMS3
Pocket No pockets
ColabFold model
FPocket 0.752 · Pocket 12
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 7 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0015627 A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex.
  • GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
32 165 Gene3D G3DSA:3.55.40.10 minor pseudopilin epsh domain
35 171 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
3 164 NCBIfam TIGR01708 type II secretion system minor pseudopilin GspH
3 164 InterPro IPR002416 Type II secretion system protein GspH
3 26 NCBIfam TIGR02532 prepilin-type N-terminal cleavage/methylation domain
3 26 InterPro IPR012902 Prokaryotic N-terminal methylation site
131 146 PRINTS PR00885 Bacterial general secretion pathway protein H signature
131 146 InterPro IPR002416 Type II secretion system protein GspH
1 15 PRINTS PR00885 Bacterial general secretion pathway protein H signature
1 15 InterPro IPR002416 Type II secretion system protein GspH
16 30 PRINTS PR00885 Bacterial general secretion pathway protein H signature
16 30 InterPro IPR002416 Type II secretion system protein GspH
2 26 Pfam PF07963 Prokaryotic N-terminal methylation motif
2 26 InterPro IPR012902 Prokaryotic N-terminal methylation site
1 13 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 22 SignalP_EUK SignalP-TM SignalP-TM
4 24 ProSitePatterns PS00409 Prokaryotic N-terminal methylation site.
4 24 InterPro IPR012902 Prokaryotic N-terminal methylation site
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
30 34 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
14 29 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
6 140 SUPERFAMILY SSF54523 Pili subunits
6 140 InterPro IPR045584 Pilin-like
1 34 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GMS3
AlphaFold — — full sequence — Viewing
ColabFold KP13_01841
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
13 0.372
2 0.307
7 0.233