Protein profile

KP13_01844

General secretion pathway protein K

Genome: KpKP13

Gene: AHE46284.1 pulK Structure source: AlphaFold + ColabFold UniProt A0A0H3GJJ1
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Amino acids 317
Annotations 3
Features 25
PDB binders 0
Druggability 0.921

Overview

Basic information about this protein and its source genome.

Accession
KP13_01844
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46284.1 pulK
Status
annotated
Amino acids
317
Structure source
AlphaFold + ColabFold
GO
GO:0009306 The controlled release of proteins from a cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
93.11

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.921
Structure A0A0H3GJJ1
Pocket Pocket 1
P2Rank 0.647
Structure A0A0H3GJJ1
Pocket Pocket 1
ColabFold model
FPocket 0.913 · Pocket 1
P2Rank 0.452 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 7 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0009306 The controlled release of proteins from a cell.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
1 305 NCBIfam NF037980 type II secretion system minor pseudopilin GspK
1 305 InterPro IPR005628 General secretion pathway protein K
91 201 SUPERFAMILY SSF158544 GspK insert domain-like
91 201 InterPro IPR038072 GspK, central domain superfamily
21 302 Pfam PF03934 Type II secretion system (T2SS), protein K
21 302 InterPro IPR005628 General secretion pathway protein K
13 17 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
204 270 SUPERFAMILY SSF158544 GspK insert domain-like
204 270 InterPro IPR038072 GspK, central domain superfamily
34 294 Gene3D G3DSA:3.30.1300.30 -
1 17 SignalP_EUK SignalP-noTM SignalP-noTM
2 12 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 21 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 15 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 1 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
18 317 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
27 308 SUPERFAMILY SSF54523 Pili subunits
27 308 InterPro IPR045584 Pilin-like
1 17 Phobius SIGNAL_PEPTIDE Signal peptide region
89 203 Gene3D G3DSA:1.10.40.60 -
89 203 InterPro IPR038072 GspK, central domain superfamily
204 270 Gene3D G3DSA:1.10.40.60 -
1 311 PANTHER PTHR38831 TYPE II SECRETION SYSTEM PROTEIN K
1 311 InterPro IPR005628 General secretion pathway protein K
1 311 PIRSF PIRSF002786 XcpX

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GJJ1
AlphaFold — — full sequence — Viewing
ColabFold KP13_01844
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.921
13 0.498

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.44 0.507
2 1.21 0.011