Protein profile

KP13_01851

sugar fermentation stimulation protein

Genome: KpKP13

Gene: sfsA AHE46291.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GMR4
Export view
Amino acids 238
Annotations 1
Features 16
PDB binders 0
Druggability 0.296

Overview

Basic information about this protein and its source genome.

Accession
KP13_01851
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
sfsA AHE46291.1
Status
annotated
Amino acids
238
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
96.52

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.296
Structure A0A0H3GMR4
Pocket Pocket 5
P2Rank 0.634
Structure A0A0H3GMR4
Pocket Pocket 1
ColabFold model
FPocket 0.304 · Pocket 11
P2Rank 0.666 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 146 / 4744 genomes with a hit
Normalized 0.031

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
11 233 CDD cd22359 SfsA-like_bacterial
11 233 InterPro IPR005224 Sugar fermentation stimulation protein
3 233 NCBIfam TIGR00230 DNA/RNA nuclease SfsA
3 233 InterPro IPR005224 Sugar fermentation stimulation protein
84 221 Pfam PF03749 Sugar fermentation stimulation protein RE domain
84 221 InterPro IPR040452 Sugar fermentation stimulation protein, C-terminal
81 234 Gene3D G3DSA:3.40.1350.60 -
1 80 Gene3D G3DSA:2.40.50.580 -
3 234 PANTHER PTHR30545 SUGAR FERMENTATION STIMULATION PROTEIN A
3 234 InterPro IPR005224 Sugar fermentation stimulation protein
81 234 FunFam G3DSA:3.40.1350.60:FF:000001 Sugar fermentation stimulation protein A
1 234 Hamap MF_00095 Sugar fermentation stimulation protein A [sfsA].
1 234 InterPro IPR005224 Sugar fermentation stimulation protein
13 79 Pfam PF17746 SfsA N-terminal OB domain
13 79 InterPro IPR041465 SfsA, N-terminal OB domain
1 80 FunFam G3DSA:2.40.50.580:FF:000001 Sugar fermentation stimulation protein A

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GMR4
AlphaFold — — full sequence — Viewing
ColabFold KP13_01851
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.296
13 0.282

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.52 0.455
2 1.96 0.041
3 0.64 0.001