Protein profile

KP13_01859

Glycoside hydrolase/deacetylase domain-containing protein

Genome: KpKP13

Gene: AHE46299.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GJG9
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Amino acids 417
Annotations 2
Features 17
PDB binders 0
Druggability 0.106

Overview

Basic information about this protein and its source genome.

Accession
KP13_01859
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46299.1
Status
annotated
Amino acids
417
Structure source
AlphaFold + ColabFold
GO
GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016810 Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
90.93

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.106
Structure A0A0H3GJG9
Pocket Pocket 28
P2Rank 0.347
Structure A0A0H3GJG9
Pocket Pocket 1
ColabFold model
FPocket 0.052 · Pocket 27
P2Rank 0.423 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 84 / 4744 genomes with a hit
Normalized 0.018

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0016810 Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
1 19 SignalP_EUK SignalP-noTM SignalP-noTM
1 21 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region
238 407 CDD cd10966 CE4_yadE_5s
18 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
168 412 Gene3D G3DSA:3.20.20.370 Glycoside hydrolase/deacetylase
1 21 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
240 417 ProSiteProfiles PS51677 NodB homology domain profile.
240 417 InterPro IPR002509 NodB homology domain
26 417 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
199 389 SUPERFAMILY SSF88713 Glycoside hydrolase/deacetylase
199 389 InterPro IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
236 375 Pfam PF01522 Polysaccharide deacetylase
236 375 InterPro IPR002509 NodB homology domain
3 415 PANTHER PTHR34216 -
7 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GJG9
AlphaFold — — full sequence — Viewing
ColabFold KP13_01859
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.28 0.176
2 2.7 0.08
3 1.97 0.041