Protein profile

KP13_01860

Putative phosphotransferase enzyme IIA component

Genome: KpKP13

Gene: AHE46300.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GNE2
Export view
Amino acids 146
Annotations 4
Features 10
PDB binders 0
Druggability 0.204

Overview

Basic information about this protein and its source genome.

Accession
KP13_01860
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46300.1
Status
annotated
Amino acids
146
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401 The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
69.444
DEG E-value
2.61e-74
Localization
Unknown
ColabFold pLDDT
91.51

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.204
Structure A0A0H3GNE2
Pocket Pocket 2
P2Rank 0.02
Structure A0A0H3GNE2
Pocket Pocket 1
ColabFold model
FPocket 0.211 · Pocket 7
P2Rank 0.021 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 59 / 4744 genomes with a hit
Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0009401 The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
3 120 CDD cd00006 PTS_IIA_man
3 120 InterPro IPR033887 PTS system mannose/sorbose specific IIA subunit
1 136 Gene3D G3DSA:3.40.50.510 -
1 136 InterPro IPR036662 Phosphotransferase system, mannose-type IIA component superfamily
1 124 ProSiteProfiles PS51096 PTS_EIIA type-4 domain profile.
1 124 InterPro IPR004701 Phosphotransferase system, mannose-type IIA component
1 124 SUPERFAMILY SSF53062 PTS system fructose IIA component-like
1 124 InterPro IPR036662 Phosphotransferase system, mannose-type IIA component superfamily
3 114 Pfam PF03610 PTS system fructose IIA component
3 114 InterPro IPR004701 Phosphotransferase system, mannose-type IIA component

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GNE2
AlphaFold — — full sequence — Viewing
ColabFold KP13_01860
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.204