Protein profile

KP13_01864

Hypoxanthine phosphoribosyltransferase

Genome: KpKP13

Gene: AHE46304.1 hpt Structure source: AlphaFold + ColabFold UniProt A0A0H3GJG3
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Amino acids 182
Annotations 11
Features 12
PDB binders 16
Druggability 0.149

Overview

Basic information about this protein and its source genome.

Accession
KP13_01864
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46304.1 hpt
Status
annotated
Amino acids
182
Structure source
AlphaFold + ColabFold
EC
2.4.2.8
GO
GO:0006166 Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. GO:0004422 Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0052657 Catalysis of the reaction: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate. GO:0000287 Binding to a magnesium (Mg) ion. GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
35.057
Human E-value
4.05e-26
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
50.877
DEG E-value
7.649999999999999e-52
Localization
Cytoplasmic
ColabFold pLDDT
93.19

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.149
Structure A0A0H3GJG3
Pocket Pocket 6
P2Rank 0.409
Structure A0A0H3GJG3
Pocket Pocket 1
ColabFold model
FPocket 0.264 · Pocket 1
P2Rank 0.323 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 1201 / 4744 genomes with a hit
Normalized 0.253

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 10 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

10
  • GO:0006166 Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis.
  • GO:0004422 Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0052657 Catalysis of the reaction: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.
  • GO:0000287 Binding to a magnesium (Mg) ion.
  • GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
  • GO:0032263 Any process which produces guanosine monophosphate from derivatives of it, without de novo synthesis.
  • GO:0006178 Any process that generates guanine, 2-amino-6-hydroxypurine, from derivatives of it without de novo synthesis.
  • GO:0046100 The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate.
  • GO:0032264 Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
22 140 CDD cd06223 PRTases_typeI
22 140 InterPro IPR000836 Phosphoribosyltransferase domain
4 180 FunFam G3DSA:3.40.50.2020:FF:000006 Hypoxanthine phosphoribosyltransferase
11 177 NCBIfam TIGR01203 hypoxanthine phosphoribosyltransferase
11 177 InterPro IPR005904 Hypoxanthine phosphoribosyl transferase
17 164 Pfam PF00156 Phosphoribosyl transferase domain
17 164 InterPro IPR000836 Phosphoribosyltransferase domain
1 181 Gene3D G3DSA:3.40.50.2020 -
1 181 InterPro IPR029057 Phosphoribosyltransferase-like
3 177 SUPERFAMILY SSF53271 PRTase-like
3 177 InterPro IPR029057 Phosphoribosyltransferase-like
6 177 PANTHER PTHR43340 HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GJG3
AlphaFold — — full sequence — Viewing
ColabFold KP13_01864
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.23 0.112
2 1.48 0.02

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

74 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
3L5
5KNR
P0A9M2 454.3 Da LogP -1.62 TPSA 217.1 1 viol. ✓ Clean c1nc2c(n1CCN(CCOCCP(=O)(O)O)CCP(=O)(O)O)NC(=NC2…
3L7
5KNS
P0A9M2 437.3 Da LogP -0.74 TPSA 191.1 ✓ Ro5 ✓ Clean c1nc2c(n1CCN(CCO/C=C/P(=O)(O)O)CCP(=O)(O)O)N=CN…
3QE
4RHU
P9WHQ9 441.3 Da LogP -1.54 TPSA 223.1 1 viol. ✓ Clean c1nc2c(n1C[C@H](COCCP(=O)(O)O)OCCP(=O)(O)O)N=C(…
3QF
4RHX
P9WHQ9 495.4 Da LogP -2.14 TPSA 228.2 1 viol. ✓ Clean c1nc2c(n1CCN(CCN(CCP(=O)(O)O)CC=O)CCP(=O)(O)O)N…
3QG
4RHY
P9WHQ9 546.4 Da LogP -1.74 TPSA 242.6 2 viol. ✓ Clean c1nc2c(n1CCN(CCN(CCP(=O)(O)O)CCP(=O)(O)O)CCP(=O…
45T
4RHU
P9WHQ9 441.3 Da LogP -1.54 TPSA 223.1 1 viol. ✓ Clean c1nc2c(n1C[C@@H](COCCP(=O)(O)O)OCCP(=O)(O)O)N=C…
5GP
1G9T
P0A9M2 363.2 Da LogP -2.57 TPSA 206.0 1 viol. ✓ Clean c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O…
6W7
5KNP
P9WHQ9 315.2 Da LogP -1.22 TPSA 142.4 ✓ Ro5 ✓ Clean c1nc2c(n1[C@@H]3CNC[C@@H]3OCP(=O)(O)O)N=CNC2=O
6W9
5KNV
P0A9M2 423.3 Da LogP -0.44 TPSA 181.9 ✓ Ro5 ✓ Clean c1nc2c(n1CCN(CCCCP(=O)(O)O)CCP(=O)(O)O)N=CNC2=O
6WA
5KNU
P0A9M2 408.3 Da LogP 0.19 TPSA 179.8 1 viol. ✓ Clean c1c(c2c([nH]1)C(=O)NC=N2)CN(CCCP(=O)(O)O)CCCP(=…
6WB
5KNT
P0A9M2 361.3 Da LogP -2.05 TPSA 164.8 ✓ Ro5 ✓ Clean c1nc2c(n1CCN(CCP(=O)(O)O)C[C@@H](CO)O)N=CNC2=O
6WC
5KNX
P0A9M2 412.2 Da LogP -0.96 TPSA 197.1 ✓ Ro5 ✓ Clean c1nc2c(n1CC(COCP(=O)(O)O)COCP(=O)(O)O)N=CNC2=O
FMB
1TC1
Q4DRC4 268.2 Da LogP -2.20 TPSA 144.4 ✓ Ro5 ✓ Clean C1=Nc2c(n[nH]c2C(=O)N1)[C@H]3[C@@H]([C@@H]([C@H…
G4P
6D9S
B9ZW32 603.2 Da LogP -2.22 TPSA 345.6 3 viol. ✓ Clean c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O…
IMP
1G9S
P0A9M2 348.2 Da LogP -2.15 TPSA 180.0 ✓ Ro5 ✓ Clean c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O…
POP
4RHT
P9WHQ9 176.0 Da LogP -2.08 TPSA 129.9 ✓ Ro5 ✓ Clean O[P@@](=O)([O-])O[P@@](=O)(O)[O-]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.