Protein profile

KP13_01886

Protein ampE

Genome: KpKP13

Gene: ampE AHE46326.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GI93
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Amino acids 284
Annotations 2
Features 20
PDB binders 0
Druggability 0.559

Overview

Basic information about this protein and its source genome.

Accession
KP13_01886
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ampE AHE46326.1
Status
annotated
Amino acids
284
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
85.61

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.559
Structure A0A0H3GI93
Pocket Pocket 24
P2Rank 0.685
Structure A0A0H3GI93
Pocket Pocket 1
ColabFold model
FPocket 0.889 · Pocket 21
P2Rank 0.532 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 91 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
146 168 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 283 PANTHER PTHR38684 PROTEIN AMPE
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
11 14 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
169 265 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
3 10 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
65 85 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
266 283 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
266 283 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
148 168 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
38 57 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
15 37 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
86 147 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
70 92 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 284 Pfam PF17113 Regulatory signalling modulator protein AmpE
1 284 InterPro IPR031347 Protein AmpE
284 284 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 14 Phobius SIGNAL_PEPTIDE Signal peptide region
38 58 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
59 64 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GI93
AlphaFold — — full sequence — Viewing
ColabFold KP13_01886
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.056
2 0.019
1 0.014
9 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.9 0.685
2 8.32 0.378
3 7.88 0.352
4 5.1 0.192
5 3.75 0.116