Protein profile

KP13_01891

putative protein transporter

Genome: KpKP13

Gene: AHE46331.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GI88
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Amino acids 380
Annotations 4
Features 35
PDB binders 1
Druggability 0.892

Overview

Basic information about this protein and its source genome.

Accession
KP13_01891
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46331.1
Status
annotated
Amino acids
380
Structure source
AlphaFold + ColabFold
GO
GO:0009306 The controlled release of proteins from a cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
85.52

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.892
Structure A0A0H3GI88
Pocket Pocket 25
P2Rank 0.084
Structure A0A0H3GI88
Pocket Pocket 1
ColabFold model
FPocket 0.798 · Pocket 8
P2Rank 0.171 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 68 / 4744 genomes with a hit
Normalized 0.014

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0009306 The controlled release of proteins from a cell.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.

Sequence Features

Domain/signature hits from InterPro and related databases.

35 records
Show feature table
Start End DB Term Name
229 251 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
142 164 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
27 144 FunFam G3DSA:1.20.81.30:FF:000001 Type II secretion system protein F
347 369 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
210 228 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
226 248 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
356 375 PRINTS PR00812 Bacterial general secretion pathway protein F signature
356 375 InterPro IPR003004 GspF/PilC family
340 354 PRINTS PR00812 Bacterial general secretion pathway protein F signature
340 354 InterPro IPR003004 GspF/PilC family
137 165 PRINTS PR00812 Bacterial general secretion pathway protein F signature
137 165 InterPro IPR003004 GspF/PilC family
38 50 PRINTS PR00812 Bacterial general secretion pathway protein F signature
38 50 InterPro IPR003004 GspF/PilC family
367 380 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
229 345 FunFam G3DSA:1.20.81.30:FF:000001 Type II secretion system protein F
348 366 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
141 164 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
39 144 Gene3D G3DSA:1.20.81.30 Type II secretion system (T2SS), domain F
39 144 InterPro IPR042094 Type II secretion system GspF domain superfamily
248 367 Pfam PF00482 Type II secretion system (T2SS), protein F
248 367 InterPro IPR018076 Type II secretion system protein GspF domain
43 165 Pfam PF00482 Type II secretion system (T2SS), protein F
43 165 InterPro IPR018076 Type II secretion system protein GspF domain
252 347 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
165 183 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
3 375 PANTHER PTHR30012 GENERAL SECRETION PATHWAY PROTEIN
3 375 InterPro IPR003004 GspF/PilC family
184 209 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
137 165 ProSitePatterns PS00874 Bacterial type II secretion system protein F signature.
137 165 InterPro IPR001992 T2SS_GspF/T4SS_PilC conserved site
1 140 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
191 213 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
229 339 Gene3D G3DSA:1.20.81.30 Type II secretion system (T2SS), domain F
229 339 InterPro IPR042094 Type II secretion system GspF domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GI88
AlphaFold — — full sequence — Viewing
ColabFold KP13_01891
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
25 0.892
36 0.774
5 0.525
12 0.424

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.01 0.043
2 0.81 0.003

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
PE5
3C1Q
P45780 398.5 Da LogP 0.13 TPSA 94.1 ✓ Ro5 ✓ Clean CCOCCOCCOCCOCCOCCOCCOCCOCCO

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.