Protein profile

KP13_01898

Secretion monitor

Genome: KpKP13

Gene: secM AHE46338.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GN99
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Amino acids 167
Annotations 3
Features 11
PDB binders 0
Druggability 0.898

Overview

Basic information about this protein and its source genome.

Accession
KP13_01898
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
secM AHE46338.1
Status
annotated
Amino acids
167
Structure source
AlphaFold + ColabFold
GO
GO:0045182 Any molecular function involved in the regulation of initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
72.674
DEG E-value
5.510000000000001e-79
Localization
Cytoplasmic
ColabFold pLDDT
59.11

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.898
Structure A0A0H3GN99
Pocket Pocket 10
P2Rank
Structure A0A0H3GN99
Pocket No pockets
ColabFold model
FPocket 0.793 · Pocket 5
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 81 / 4744 genomes with a hit
Normalized 0.017

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0045182 Any molecular function involved in the regulation of initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
34 39 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
26 164 Pfam PF06558 Secretion monitor precursor protein (SecM)
26 164 InterPro IPR009502 Secretion monitor
1 21 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
40 167 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
3 167 Hamap MF_01332 Secretion monitor [secM].
3 167 InterPro IPR009502 Secretion monitor
3 167 PIRSF PIRSF004572 SecM
22 33 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 39 Phobius SIGNAL_PEPTIDE Signal peptide region
1 29 SignalP_EUK SignalP-noTM SignalP-noTM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GN99
AlphaFold — — full sequence — Viewing
ColabFold KP13_01898
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.898