Protein profile

KP13_01914

Protein mraZ

Genome: KpKP13

Gene: AHE46355.1 mraZ Structure source: AlphaFold + ColabFold UniProt A0A0H3GRP6
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Amino acids 152
Annotations 3
Features 22
PDB binders 0
Druggability 0.272

Overview

Basic information about this protein and its source genome.

Accession
KP13_01914
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46355.1 mraZ
Status
annotated
Amino acids
152
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
93.421
DEG E-value
1.2299999999999999e-104
Localization
Cytoplasmic
ColabFold pLDDT
94.96

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.272
Structure A0A0H3GRP6
Pocket Pocket 1
P2Rank 0.143
Structure A0A0H3GRP6
Pocket Pocket 1
ColabFold model
FPocket 0.489 · Pocket 2
P2Rank 0.116 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 144 / 4744 genomes with a hit
Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
1 143 FunFam G3DSA:3.40.1550.20:FF:000001 Transcriptional regulator MraZ
3 64 CDD cd16320 MraZ_N
3 64 InterPro IPR035642 MraZ, N-terminal
1 152 NCBIfam TIGR00242 division/cell wall cluster transcriptional repressor MraZ
1 152 InterPro IPR003444 Transcriptional regulator MraZ
1 135 SUPERFAMILY SSF89447 AbrB/MazE/MraZ-like
1 135 InterPro IPR037914 SpoVT-AbrB domain superfamily
71 132 CDD cd16321 MraZ_C
71 132 InterPro IPR035644 MraZ, C-terminal
1 152 Hamap MF_01008 Transcriptional regulator MraZ [mraZ].
1 147 Gene3D G3DSA:3.40.1550.20 Transcriptional regulator MraZ domain
1 147 InterPro IPR038619 MraZ superfamily
1 75 Pfam PF02381 MraZ protein, putative antitoxin-like
1 75 InterPro IPR020603 MraZ domain
77 138 Pfam PF02381 MraZ protein, putative antitoxin-like
77 138 InterPro IPR020603 MraZ domain
5 52 ProSiteProfiles PS51740 SpoVT-AbrB domain profile.
5 52 InterPro IPR007159 SpoVT-AbrB domain
1 151 PANTHER PTHR34701 TRANSCRIPTIONAL REGULATOR MRAZ
1 151 InterPro IPR003444 Transcriptional regulator MraZ
81 124 ProSiteProfiles PS51740 SpoVT-AbrB domain profile.
81 124 InterPro IPR007159 SpoVT-AbrB domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRP6
AlphaFold — — full sequence — Viewing
ColabFold KP13_01914
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.272

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.61 0.135
2 1.71 0.03
3 1.42 0.018