Protein profile

KP13_01927

Inner membrane transport protein

Genome: KpKP13

Gene: AHE46369.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GN71
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Amino acids 405
Annotations 4
Features 51
PDB binders 0
Druggability 0.403

Overview

Basic information about this protein and its source genome.

Accession
KP13_01927
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46369.1
Status
annotated
Amino acids
405
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
58.354
DEG E-value
1.4400000000000001e-164
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.73

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.403
Structure A0A0H3GN71
Pocket Pocket 2
P2Rank 0.938
Structure A0A0H3GN71
Pocket Pocket 1
ColabFold model
FPocket 0.779 · Pocket 10
P2Rank 0.939 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 40 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

51 records
Show feature table
Start End DB Term Name
303 325 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
357 361 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
277 299 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
2 395 PANTHER PTHR23514 BYPASS OF STOP CODON PROTEIN 6
133 155 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
271 276 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
12 32 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
4 193 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
4 193 InterPro IPR036259 MFS transporter superfamily
10 391 SUPERFAMILY SSF103473 MFS general substrate transporter
10 391 InterPro IPR036259 MFS transporter superfamily
234 244 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
277 299 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
62 78 ProSitePatterns PS00216 Sugar transport proteins signature 1.
62 78 InterPro IPR005829 Sugar transporter, conserved site
133 154 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
328 338 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
365 387 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
73 91 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
388 405 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
14 312 Pfam PF07690 Major Facilitator Superfamily
14 312 InterPro IPR011701 Major facilitator superfamily
96 112 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
339 356 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
9 390 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
9 390 InterPro IPR020846 Major facilitator superfamily domain
95 112 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
338 355 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
159 181 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
251 270 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
12 34 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
180 211 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
44 66 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
33 43 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
44 66 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
208 390 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
208 390 InterPro IPR036259 MFS transporter superfamily
362 387 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
214 236 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
212 233 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
305 327 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
300 304 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
4 191 FunFam G3DSA:1.20.1250.20:FF:000135 MFS family transporter
73 90 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
245 270 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
155 159 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
113 132 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
67 72 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
160 179 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
91 95 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GN71
AlphaFold — — full sequence — Viewing
ColabFold KP13_01927
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.403
27 0.402
1 0.378
4 0.267

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 27.22 0.919
2 3.37 0.12
3 2.29 0.058
4 1.66 0.028
5 1.58 0.025