Protein profile

KP13_01931

Sugar efflux transporter A

Genome: KpKP13

Gene: AHE46372.1 setA Structure source: AlphaFold + ColabFold UniProt A0A0H3GJ68
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Amino acids 394
Annotations 9
Features 55
PDB binders 0
Druggability 0.442

Overview

Basic information about this protein and its source genome.

Accession
KP13_01931
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46372.1 setA
Status
annotated
Amino acids
394
Structure source
AlphaFold + ColabFold
GO
GO:0005351 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in). GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0008643 The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
87.23

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.442
Structure A0A0H3GJ68
Pocket Pocket 1
P2Rank 0.933
Structure A0A0H3GJ68
Pocket Pocket 1
ColabFold model
FPocket 0.733 · Pocket 1
P2Rank 0.967 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 100 / 4744 genomes with a hit
Normalized 0.021

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

9 GO

Gene Ontology (GO)

9
  • GO:0005351 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in).
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0008643 The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0036448 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the accumulation of glucose-phosphate.
  • GO:1904659 The process in which D-glucose is transported across a membrane.
  • GO:0015767 The directed movement of lactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals.

Sequence Features

Domain/signature hits from InterPro and related databases.

55 records
Show feature table
Start End DB Term Name
48 70 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
25 32 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
13 24 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
365 369 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
17 393 NCBIfam TIGR00899 sugar efflux transporter
17 393 InterPro IPR004750 Sugar efflux
256 277 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
168 190 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 12 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
278 285 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
128 138 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
139 156 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
12 199 FunFam G3DSA:1.20.1250.20:FF:000125 Sugar efflux transporter SetB
18 387 CDD cd17471 MFS_Set
82 99 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
82 99 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
309 331 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
14 394 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
14 394 InterPro IPR020846 Major facilitator superfamily domain
310 331 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
370 388 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
191 221 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
338 360 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
71 81 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
139 158 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
389 394 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
305 309 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
222 244 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
254 276 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
100 104 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
7 394 PANTHER PTHR23535 SUGAR EFFLUX TRANSPORTER A-RELATED
33 47 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
222 244 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
12 206 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
12 206 InterPro IPR036259 MFS transporter superfamily
214 393 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
214 393 InterPro IPR036259 MFS transporter superfamily
332 342 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
168 190 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
11 33 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
214 393 FunFam G3DSA:1.20.1250.20:FF:000151 Sugar efflux transporter SetB
19 336 Pfam PF07690 Major Facilitator Superfamily
19 336 InterPro IPR011701 Major facilitator superfamily
288 305 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
245 255 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
343 364 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
286 304 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
157 167 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
370 389 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
48 70 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
13 389 SUPERFAMILY SSF103473 MFS general substrate transporter
13 389 InterPro IPR036259 MFS transporter superfamily
105 127 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 32 Phobius SIGNAL_PEPTIDE Signal peptide region
104 126 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GJ68
AlphaFold — — full sequence — Viewing
ColabFold KP13_01931
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.442

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 21.49 0.87
2 14.02 0.708
3 3.52 0.129
4 2.74 0.083
5 2.42 0.065