Protein profile

KP13_01934

HTH-type transcriptional regulator sgrR

Genome: KpKP13

Gene: sgrR AHE46375.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GI48
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Amino acids 551
Annotations 3
Features 14
PDB binders 1
Druggability 0.949

Overview

Basic information about this protein and its source genome.

Accession
KP13_01934
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
sgrR AHE46375.1
Status
annotated
Amino acids
551
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:1904680 Enables the transfer of a peptide from one side of a membrane to the other. GO:0015833 The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
91.28

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.949
Structure A0A0H3GI48
Pocket Pocket 1
P2Rank 0.974
Structure A0A0H3GI48
Pocket Pocket 1
ColabFold model
FPocket 0.895 · Pocket 1
P2Rank 0.965 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 104 / 4744 genomes with a hit
Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:1904680 Enables the transfer of a peptide from one side of a membrane to the other.
  • GO:0015833 The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
134 546 PANTHER PTHR30290 PERIPLASMIC BINDING COMPONENT OF ABC TRANSPORTER
134 546 InterPro IPR039424 Solute-binding protein family 5
21 84 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
21 84 InterPro IPR036390 Winged helix DNA-binding domain superfamily
6 106 Gene3D G3DSA:1.10.10.10 -
6 106 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
165 306 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle
165 306 InterPro IPR000914 Solute-binding protein family 5 domain
116 547 CDD cd08507 PBP2_SgrR_like
5 118 Pfam PF12793 Sugar transport-related sRNA regulator N-term
5 118 InterPro IPR025370 Transcriptional regulator SgrR, N-terminal HTH domain
117 548 SUPERFAMILY SSF53850 Periplasmic binding protein-like II
115 313 FunFam G3DSA:3.40.190.10:FF:000070 HTH-type transcriptional regulator SgrR
114 313 Gene3D G3DSA:3.40.190.10 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GI48
AlphaFold — — full sequence — Viewing
ColabFold KP13_01934
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.949
2 0.471

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 33.58 0.947
2 6.86 0.352

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
OXL
4OEV
Q0P844 88.0 Da LogP -3.51 TPSA 80.3 ✓ Ro5 ✓ Clean C(=O)(C(=O)[O-])[O-]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.