Protein profile

KP13_01949

Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase

Genome: KpKP13

Gene: citX AHE46387.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GN49
Export view
Amino acids 164
Annotations 3
Features 3
PDB binders 0
Druggability 0.394

Overview

Basic information about this protein and its source genome.

Accession
KP13_01949
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
citX AHE46387.1
Status
annotated
Amino acids
164
Structure source
AlphaFold + ColabFold
EC
2.7.7.61
GO
GO:0051191 The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein. GO:0050519 Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = diphosphate + holo-citrate lyase.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
93.76

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.394
Structure A0A0H3GN49
Pocket Pocket 5
P2Rank 0.512
Structure A0A0H3GN49
Pocket Pocket 1
ColabFold model
FPocket 0.582 · Pocket 10
P2Rank 0.368 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 38 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0051191 The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein.
  • GO:0050519 Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = diphosphate + holo-citrate lyase.

Sequence Features

Domain/signature hits from InterPro and related databases.

3 records
Show feature table
Start End DB Term Name
1 159 Pfam PF03802 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
1 159 InterPro IPR005551 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
1 159 NCBIfam TIGR03124 citrate lyase holo-[acyl-carrier protein] synthase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GN49
AlphaFold — — full sequence — Viewing
ColabFold KP13_01949
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.394

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.65 0.337