Protein profile

KP13_01953

DnaJ-like protein djlA

Genome: KpKP13

Gene: AHE46392.1 djlA Structure source: AlphaFold + ColabFold UniProt A0A0H3GN44
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Amino acids 275
Annotations 2
Features 32
PDB binders 0
Druggability 0.968

Overview

Basic information about this protein and its source genome.

Accession
KP13_01953
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46392.1 djlA
Status
annotated
Amino acids
275
Structure source
AlphaFold + ColabFold
GO
GO:0051087 Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
83.5

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.968
Structure A0A0H3GN44
Pocket Pocket 4
P2Rank 0.029
Structure A0A0H3GN44
Pocket Pocket 1
ColabFold model
FPocket 0.851 · Pocket 19
P2Rank 0.046 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 132 / 4744 genomes with a hit
Normalized 0.028

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0051087 Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

32 records
Show feature table
Start End DB Term Name
131 271 SUPERFAMILY SSF46565 Chaperone J-domain
131 271 InterPro IPR036869 Chaperone J-domain superfamily
209 274 SMART SM00271 dnaj_3
209 274 InterPro IPR001623 DnaJ domain
3 275 Hamap MF_01153 Co-chaperone protein DjlA [djlA].
3 275 InterPro IPR023749 Co-chaperone DjlA
213 271 Pfam PF00226 DnaJ domain
213 271 InterPro IPR001623 DnaJ domain
185 274 Gene3D G3DSA:1.10.287.110 DnaJ domain
185 274 InterPro IPR036869 Chaperone J-domain superfamily
6 30 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
210 274 ProSiteProfiles PS50076 dnaJ domain profile.
210 274 InterPro IPR001623 DnaJ domain
36 183 FunFam G3DSA:1.10.3680.10:FF:000001 Co-chaperone protein DjlA
63 170 Pfam PF05099 Tellurite resistance protein TerB
63 170 InterPro IPR007791 Co-chaperone DjlA, N-terminal
31 275 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
187 274 FunFam G3DSA:1.10.287.110:FF:000011 Co-chaperone protein DjlA
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
57 162 CDD cd07316 terB_like_DjlA
254 274 PRINTS PR00625 DnaJ domain signature
254 274 InterPro IPR001623 DnaJ domain
212 230 PRINTS PR00625 DnaJ domain signature
212 230 InterPro IPR001623 DnaJ domain
230 245 PRINTS PR00625 DnaJ domain signature
230 245 InterPro IPR001623 DnaJ domain
214 267 CDD cd06257 DnaJ
214 267 InterPro IPR001623 DnaJ domain
64 270 PANTHER PTHR24074 CO-CHAPERONE PROTEIN DJLA
39 184 Gene3D G3DSA:1.10.3680.10 -
39 184 InterPro IPR029024 TerB-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GN44
AlphaFold — — full sequence — Viewing
ColabFold KP13_01953
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.968

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.41 0.018