Protein profile

KP13_01968

Alanyl-tRNA editing protein alaX-M

Genome: KpKP13

Gene: alaXM AHE46407.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GI15
Export view
Amino acids 209
Annotations 1
Features 7
PDB binders 0
Druggability 0.261

Overview

Basic information about this protein and its source genome.

Accession
KP13_01968
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
alaXM AHE46407.1
Status
annotated
Amino acids
209
Structure source
AlphaFold + ColabFold
GO
GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
25.847
Human E-value
6.7e-07
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
96.83

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.261
Structure A0A0H3GI15
Pocket Pocket 1
P2Rank 0.711
Structure A0A0H3GI15
Pocket Pocket 1
ColabFold model
FPocket 0.259 · Pocket 1
P2Rank 0.664 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 33 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
11 207 PANTHER PTHR43462 ALANYL-TRNA EDITING PROTEIN
1 80 SUPERFAMILY SSF50447 Translation proteins
1 80 InterPro IPR009000 Translation protein, beta-barrel domain superfamily
85 201 SUPERFAMILY SSF55186 ThrRS/AlaRS common domain
85 201 InterPro IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily
85 206 Gene3D G3DSA:3.30.980.10 -
1 83 Gene3D G3DSA:2.40.30.130 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GI15
AlphaFold — — full sequence — Viewing
ColabFold KP13_01968
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.261

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.54 0.566