Protein profile

KP13_01998

Inner membrane protein CreD

Genome: KpKP13

Gene: creD AHE46435.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GMA3
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Amino acids 452
Annotations 1
Features 26
PDB binders 0
Druggability 0.971

Overview

Basic information about this protein and its source genome.

Accession
KP13_01998
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
creD AHE46435.1
Status
annotated
Amino acids
452
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
88.89

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.971
Structure A0A0H3GMA3
Pocket Pocket 36
P2Rank 0.26
Structure A0A0H3GMA3
Pocket Pocket 1
ColabFold model
FPocket 0.958 · Pocket 4
P2Rank 0.228 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 46 / 4744 genomes with a hit
Normalized 0.01

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
27 294 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
7 26 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
314 324 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
295 313 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
344 348 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
295 313 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
326 344 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 6 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
421 452 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
325 343 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
349 367 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
349 371 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
401 420 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
368 378 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
402 420 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
27 47 Coils Coil Coil
1 430 PANTHER PTHR30092 INNER MEMBRANE PROTEIN CRED
1 430 InterPro IPR010364 Uncharacterised protein family, inner membrane CreD
1 448 PIRSF PIRSF004548 CreD
1 448 InterPro IPR010364 Uncharacterised protein family, inner membrane CreD
379 396 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
397 401 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
378 397 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
6 427 Pfam PF06123 Inner membrane protein CreD
6 427 InterPro IPR010364 Uncharacterised protein family, inner membrane CreD

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GMA3
AlphaFold — — full sequence — Viewing
ColabFold KP13_01998
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
36 0.971

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.26 0.246
2 2.94 0.095
3 1.53 0.022
4 1.52 0.022
5 1.43 0.019