Protein profile

KP13_02001

Protein creA

Genome: KpKP13

Gene: creA AHE46438.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GIW8
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Amino acids 172
Annotations 1
Features 12
PDB binders 0
Druggability 0.76

Overview

Basic information about this protein and its source genome.

Accession
KP13_02001
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
creA AHE46438.1
Status
annotated
Amino acids
172
Structure source
AlphaFold + ColabFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
82.84

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.76
Structure A0A0H3GIW8
Pocket Pocket 1
P2Rank
Structure A0A0H3GIW8
Pocket No pockets
ColabFold model
FPocket 0.339 · Pocket 2
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 136 / 4744 genomes with a hit
Normalized 0.029

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
1 36 Phobius SIGNAL_PEPTIDE Signal peptide region
15 172 PIRSF PIRSF003174 CreA
15 172 InterPro IPR010292 Uncharacterised protein family CreA
37 172 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
15 171 PANTHER PTHR37952 -
15 171 InterPro IPR010292 Uncharacterised protein family CreA
1 36 SignalP_EUK SignalP-noTM SignalP-noTM
21 29 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
30 36 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
39 170 Pfam PF05981 CreA protein
39 170 InterPro IPR010292 Uncharacterised protein family CreA
1 20 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GIW8
AlphaFold — — full sequence — Viewing
ColabFold KP13_02001
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.76