Protein profile

KP13_02002

Right origin-binding protein

Genome: KpKP13

Gene: rob AHE46439.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GMY3
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Amino acids 289
Annotations 3
Features 29
PDB binders 0
Druggability 0.611

Overview

Basic information about this protein and its source genome.

Accession
KP13_02002
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
rob AHE46439.1
Status
annotated
Amino acids
289
Structure source
AlphaFold + ColabFold
GO
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
90.41

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.611
Structure A0A0H3GMY3
Pocket Pocket 22
P2Rank 0.328
Structure A0A0H3GMY3
Pocket Pocket 1
ColabFold model
FPocket 0.483 · Pocket 22
P2Rank 0.266 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 112 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

29 records
Show feature table
Start End DB Term Name
1 266 PANTHER PTHR47504 RIGHT ORIGIN-BINDING PROTEIN
8 106 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
8 106 InterPro IPR018060 DNA binding HTH domain, AraC-type
56 121 FunFam G3DSA:1.10.10.60:FF:000030 DNA-binding transcriptional regulator SoxS
3 55 Gene3D G3DSA:1.10.10.60 -
6 55 SUPERFAMILY SSF46689 Homeodomain-like
6 55 InterPro IPR009057 Homeobox-like domain superfamily
126 288 SMART SM00871 AraC_E_bind_2
126 288 InterPro IPR010499 Bacterial transcription activator, effector binding
122 288 SUPERFAMILY SSF55136 Probable bacterial effector-binding domain
122 288 InterPro IPR011256 Regulatory factor, effector binding domain superfamily
55 100 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature.
55 100 InterPro IPR018062 HTH domain AraC-type, conserved site
3 55 FunFam G3DSA:1.10.10.60:FF:000013 DNA-binding transcriptional activator MarA
127 288 Pfam PF06445 GyrI-like small molecule binding domain
127 288 InterPro IPR029442 GyrI-like small molecule binding domain
56 121 Gene3D G3DSA:1.10.10.60 -
122 289 Gene3D G3DSA:3.20.80.10 Regulatory factor, effector binding domain
122 289 InterPro IPR011256 Regulatory factor, effector binding domain superfamily
21 104 SMART SM00342 aracneu4
21 104 InterPro IPR018060 DNA binding HTH domain, AraC-type
88 104 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
88 104 InterPro IPR020449 Transcription regulator HTH, AraC- type
73 88 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
73 88 InterPro IPR020449 Transcription regulator HTH, AraC- type
57 109 SUPERFAMILY SSF46689 Homeodomain-like
57 109 InterPro IPR009057 Homeobox-like domain superfamily
27 105 Pfam PF12833 Helix-turn-helix domain
27 105 InterPro IPR018060 DNA binding HTH domain, AraC-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GMY3
AlphaFold — — full sequence — Viewing
ColabFold KP13_02002
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
22 0.611
1 0.095
13 0.071
25 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.43 0.328
2 2.06 0.038
3 0.87 0.003
4 0.72 0.002