Protein profile

KP13_02004

hypothetical protein

Genome: KpKP13

Gene: AHE46441.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GHZ3
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Amino acids 171
Annotations 6
Features 12
PDB binders 0
Druggability 0.453

Overview

Basic information about this protein and its source genome.

Accession
KP13_02004
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46441.1
Status
annotated
Amino acids
171
Structure source
AlphaFold + ColabFold
EC
3.6.1.73
GO
GO:0103023 Catalysis of the reaction: ITP + H2O = IDP + H+ + phosphate. GO:0046872 Binding to a metal ion. GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0009117 The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates). GO:0006772 The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
96.9

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.453
Structure A0A0H3GHZ3
Pocket Pocket 1
P2Rank 0.833
Structure A0A0H3GHZ3
Pocket Pocket 1
ColabFold model
FPocket 0.501 · Pocket 1
P2Rank 0.774 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 114 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0103023 Catalysis of the reaction: ITP + H2O = IDP + H+ + phosphate.
  • GO:0046872 Binding to a metal ion.
  • GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
  • GO:0009117 The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).
  • GO:0006772 The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
7 165 Pfam PF01931 Protein of unknown function DUF84
7 165 InterPro IPR026533 Non-canonical purine NTP phosphatase/PRRC1
1 171 Gene3D G3DSA:3.90.950.10 -
1 171 InterPro IPR029001 Inosine triphosphate pyrophosphatase-like
2 171 Hamap MF_00648 Inosine/xanthosine triphosphatase.
2 171 InterPro IPR002786 Inosine/xanthosine triphosphatase
7 170 NCBIfam TIGR00258 inosine/xanthosine triphosphatase
7 170 InterPro IPR002786 Inosine/xanthosine triphosphatase
2 167 SUPERFAMILY SSF52972 ITPase-like
2 167 InterPro IPR029001 Inosine triphosphate pyrophosphatase-like
1 169 PANTHER PTHR34699 -
1 171 FunFam G3DSA:3.90.950.10:FF:000002 Inosine/xanthosine triphosphatase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GHZ3
AlphaFold — — full sequence — Viewing
ColabFold KP13_02004
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.453
4 0.404

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.78 0.625