Protein profile

KP13_02007

putative ABC transporter ATP-binding protein

Genome: KpKP13

Gene: AHE46444.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GMX9
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Amino acids 548
Annotations 9
Features 34
PDB binders 6
Druggability 0.5

Overview

Basic information about this protein and its source genome.

Accession
KP13_02007
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46444.1
Status
annotated
Amino acids
548
Structure source
AlphaFold + ColabFold
EC
3.6.1.-
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0045900 Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation. GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0043022 Binding to a ribosome. GO:0019843 Binding to a ribosomal RNA.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
35.043
Human E-value
1.64e-13
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
70.795
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
86.36

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.5
Structure A0A0H3GMX9
Pocket Pocket 4
P2Rank 0.565
Structure A0A0H3GMX9
Pocket Pocket 1
ColabFold model
FPocket 0.691 · Pocket 2
P2Rank 0.484 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 1453 / 4744 genomes with a hit
Normalized 0.306

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 8 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

8
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0045900 Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.
  • GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0043022 Binding to a ribosome.
  • GO:0019843 Binding to a ribosomal RNA.
  • GO:0000049 Binding to a transfer RNA.
  • GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

34 records
Show feature table
Start End DB Term Name
2 252 ProSiteProfiles PS50893 ATP-binding cassette, ABC transporter-type domain profile.
2 252 InterPro IPR003439 ABC transporter-like, ATP-binding domain
11 229 CDD cd03221 ABCF_EF-3
7 236 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
7 236 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
279 548 Gene3D G3DSA:3.40.50.300 -
279 548 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1 546 NCBIfam TIGR03719 energy-dependent translational throttle protein EttA
1 546 InterPro IPR022374 Energy-dependent translational throttle protein EttA
317 511 CDD cd03221 ABCF_EF-3
295 519 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
295 519 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1 547 PANTHER PTHR43858 ENERGY-DEPENDENT TRANSLATIONAL THROTTLE PROTEIN ETTA
1 547 InterPro IPR022374 Energy-dependent translational throttle protein EttA
2 279 FunFam G3DSA:3.40.50.300:FF:000011 Putative ABC transporter ATP-binding component
1 538 Hamap MF_00847 Energy-dependent translational throttle protein EttA [ettA].
1 538 InterPro IPR022374 Energy-dependent translational throttle protein EttA
280 548 FunFam G3DSA:3.40.50.300:FF:000183 ABC transporter ATP-binding protein yjjK
156 170 ProSitePatterns PS00211 ABC transporters family signature.
156 170 InterPro IPR017871 ABC transporter-like, conserved site
223 299 Pfam PF12848 ABC transporter
223 299 InterPro IPR032781 ABC-transporter extension domain
15 184 Pfam PF00005 ABC transporter
15 184 InterPro IPR003439 ABC transporter-like, ATP-binding domain
333 466 Pfam PF00005 ABC transporter
333 466 InterPro IPR003439 ABC transporter-like, ATP-binding domain
317 543 ProSiteProfiles PS50893 ATP-binding cassette, ABC transporter-type domain profile.
317 543 InterPro IPR003439 ABC transporter-like, ATP-binding domain
24 229 SMART SM00382 AAA_5
24 229 InterPro IPR003593 AAA+ ATPase domain
341 515 SMART SM00382 AAA_5
341 515 InterPro IPR003593 AAA+ ATPase domain
1 278 Gene3D G3DSA:3.40.50.300 -
1 278 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GMX9
AlphaFold — — full sequence — Viewing
ColabFold KP13_02007
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.5

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.65 0.337
2 6.11 0.303
3 3.57 0.132
4 3.52 0.129
5 2.46 0.067

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

56 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
ACP
5X40
O68106 505.2 Da LogP -1.52 TPSA 269.9 3 viol. ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)…
AE3
6MJP
O30650 134.2 Da LogP 0.03 TPSA 38.7 ✓ Ro5 ✓ Clean CCOCCOCCO
ANP
6Z5U
A0A4P2WWN2 506.2 Da LogP -2.06 TPSA 281.9 3 viol. ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)…
JU7
6MJP
O30650 346.5 Da LogP 1.33 TPSA 99.4 ✓ Ro5 ✓ Clean C1CCC(CC1)CCCCCCO[C@H]2[C@@H]([C@H]([C@@H]([C@H…
LMT
6MJP
O30650 510.6 Da LogP -0.45 TPSA 178.5 3 viol. ✓ Clean CCCCCCCCCCCCO[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1…
MA4
6MJP
O30650 508.6 Da LogP -0.84 TPSA 178.5 3 viol. ✓ Clean C1CCC(CC1)CCCCCCO[C@H]2[C@@H]([C@H]([C@@H]([C@H…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.