Protein profile

KP13_32220

Osmotically-inducible protein Y

Genome: KpKP13

Gene: AHE46458.1 osmY Structure source: AlphaFold + ColabFold UniProt A0A0H3GIU5
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Amino acids 206
Annotations 1
Features 24
PDB binders 0
Druggability 0.112

Overview

Basic information about this protein and its source genome.

Accession
KP13_32220
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46458.1 osmY
Status
annotated
Amino acids
206
Structure source
AlphaFold + ColabFold
GO
GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
40.541
DEG E-value
5.7
Localization
Periplasmic
ColabFold pLDDT
79.11

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.112
Structure A0A0H3GIU5
Pocket Pocket 6
P2Rank
Structure A0A0H3GIU5
Pocket No pockets
ColabFold model
FPocket 0.26 · Pocket 12
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 86 / 4744 genomes with a hit
Normalized 0.018

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
7 131 PANTHER PTHR34606 BON DOMAIN-CONTAINING PROTEIN
57 125 ProSiteProfiles PS50914 BON domain profile.
57 125 InterPro IPR007055 BON domain
59 124 FunFam G3DSA:3.30.1340.30:FF:000001 Molecular chaperone OsmY
25 206 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
139 206 ProSiteProfiles PS50914 BON domain profile.
139 206 InterPro IPR007055 BON domain
1 24 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
57 123 Pfam PF04972 BON domain
57 123 InterPro IPR007055 BON domain
140 206 Pfam PF04972 BON domain
140 206 InterPro IPR007055 BON domain
1 24 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
141 206 FunFam G3DSA:3.30.1340.30:FF:000001 Molecular chaperone OsmY
21 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
10 20 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
141 206 Gene3D G3DSA:3.30.1340.30 -
59 124 Gene3D G3DSA:3.30.1340.30 -
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
144 205 SMART SM00749 bon
144 205 InterPro IPR014004 Transport-associated and nodulation domain, bacteria
62 125 SMART SM00749 bon
62 125 InterPro IPR014004 Transport-associated and nodulation domain, bacteria
1 9 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GIU5
AlphaFold — — full sequence — Viewing
ColabFold KP13_32220
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer