Protein profile

KP13_02026

DNA polymerase III subunit psi

Genome: KpKP13

Gene: AHE46462.1 holD Structure source: AlphaFold + ColabFold UniProt A0A0H3GRC3
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Amino acids 137
Annotations 3
Features 10
PDB binders 0
Druggability 0.352

Overview

Basic information about this protein and its source genome.

Accession
KP13_02026
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46462.1 holD
Status
annotated
Amino acids
137
Structure source
AlphaFold + ColabFold
GO
GO:0006260 The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0003887 Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. GO:0008408 Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
79.412
DEG E-value
3.67e-76
Localization
Unknown
ColabFold pLDDT
89.32

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.352
Structure A0A0H3GRC3
Pocket Pocket 8
P2Rank
Structure A0A0H3GRC3
Pocket No pockets
ColabFold model
FPocket 0.929 · Pocket 3
P2Rank 0.014 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 82 / 4744 genomes with a hit
Normalized 0.017

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006260 The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
  • GO:0003887 Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time.
  • GO:0008408 Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
1 125 NCBIfam TIGR00664 DNA polymerase III subunit psi
1 125 InterPro IPR018382 DNA polymerase III, psi subunit, subgroup
33 137 Gene3D G3DSA:3.40.50.10220 DNA polymerase III, psi subunit
33 137 InterPro IPR036654 DNA polymerase III, psi subunit superfamily
3 127 Pfam PF03603 DNA polymerase III psi subunit
3 127 InterPro IPR004615 DNA polymerase III, psi subunit
27 136 SUPERFAMILY SSF102220 DNA polymerase III psi subunit
27 136 InterPro IPR036654 DNA polymerase III, psi subunit superfamily
2 131 PIRSF PIRSF029225 DNA_pol_III_psi
2 131 InterPro IPR004615 DNA polymerase III, psi subunit

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRC3
AlphaFold — — full sequence — Viewing
ColabFold KP13_02026
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.352