Protein profile

KP13_02028

hypothetical protein

Genome: KpKP13

Gene: AHE46464.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GMW2
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Amino acids 100
Annotations 0
Features 12
PDB binders 0
Druggability 0.743

Overview

Basic information about this protein and its source genome.

Accession
KP13_02028
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46464.1
Status
annotated
Amino acids
100
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
63.85

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.743
Structure A0A0H3GMW2
Pocket Pocket 2
P2Rank 0.053
Structure A0A0H3GMW2
Pocket Pocket 1
ColabFold model
FPocket 0.951 · Pocket 4
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 50 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
52 69 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
70 75 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
76 94 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 25 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
22 94 Pfam PF07256 Protein of unknown function (DUF1435)
22 94 InterPro IPR009885 Protein of unknown function DUF1435
76 94 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
95 100 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
52 69 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
26 48 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
26 46 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
47 51 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GMW2
AlphaFold — — full sequence — Viewing
ColabFold KP13_02028
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.743

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.53 0.022
2 0.85 0.003